OBJECTIVE: To verify if patients with polycystic ovarian syndrome (PCOS), have an increased cardiovascular risk compared with healthy controls. DESIGN: Prospective case-control study. SETTING: University-based practice. PATIENT(S): Twenty eumenorrheic controls (ten lean [group A] and ten overweight [group B]) and 24 PCOS women (14 lean [group C] and ten overweight [group D]). INTERVENTION(S): Cardiovascular risk markers and hormonal parameters were assessed. MAIN OUTCOME MEASURE(S): Androgens, fasting glucose, insulin, leptin, fibrinogen, homocysteine, endothelin-1 and flow-mediated dilatation of the brachial artery were measured to investigate their relationship to weight and to PCOS. RESULT(S): The brachial artery diameter and the pulsatility index, after the reactive hyperemia, showed in group A the most intense vasodilatation compared with the other groups. Homocysteine levels did not differ among the groups. Endothelin-1 was significantly higher in group A compared with groups B and D. Leptin was significantly lower in groups A and C compared with groups B and D. Insulin resistance was higher in groups B and D. Group A had significantly higher glucose-insulin ratio compared with all of the other groups; group C had significantly higher glucose-insulin ratio only compared with group D. CONCLUSION(S): Weight and PCOS are two independent variables affecting the endothelial function.
|Data di pubblicazione:||2009|
|Titolo:||Endothelial function and its relationship to leptin, homocysteine, and insulin resistance in lean and overweight eumenorrheic women and PCOS patients: a pilot study.|
|Autore/i:||F. Mancini;A. Cianciosi;G. M. Reggiani;F. Facchinetti;C. Battaglia;D. d. Aloysio|
|Digital Object Identifier (DOI):||10.1016/j.fertnstert.2008.03.023|
|Codice identificativo ISI:||WOS:000266801400039|
|Codice identificativo Scopus:||2-s2.0-67349198880|
|Codice identificativo Pubmed:||18462732|
|Citazione:||Endothelial function and its relationship to leptin, homocysteine, and insulin resistance in lean and overweight eumenorrheic women and PCOS patients: a pilot study. / F. Mancini;A. Cianciosi;G. M. Reggiani;F. Facchinetti;C. Battaglia;D. d. Aloysio. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - STAMPA. - 91(2009), pp. 2537-2544.|
|Tipologia||Articolo su rivista|
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