Different types of cells from subjects with Down syndrome (DS) have an increased susceptibility to cell death. We have studied apoptosis and mitochondrial (mt) membrane potential (Delta Psi(m)) in peripheral blood mononuclear cells (PBMC) from DS children and age-matched healthy donors after in vitro treatment with apoptogenic molecules, along with mtDNA content. We found that PBMC from DS and healthy controls had a similar tendency to undergo apoptosis and a similar amount of mtDNA. However, in cells from DS subjects, mitochondria showed a higher loss of Delta Psi(m), underlying the presence of an increasing susceptibility of these organelles to damaging agents. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.</div>

Mitochondrial alterations and tendency to apoptosis in peripheral blood cells from children with Down syndrome / Roat, Erika; Prada, Nicole; Ferraresi, Roberta; Giovenzana, Chiara; Nasi, Milena; Troiano, Leonarda; Nemes, Elisa; Pinti, Marcello; Lugli, Enrico; O., Biagioni; M., Mariotti; L., Ciacci; Consolo, Ugo; Balli, Fiorella; Cossarizza, Andrea. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 581:3(2007), pp. 521-525. [10.1016/j.febslet.2006.12.058]

Mitochondrial alterations and tendency to apoptosis in peripheral blood cells from children with Down syndrome.

ROAT, ERIKA;PRADA, Nicole;FERRARESI, Roberta;GIOVENZANA, Chiara;NASI, Milena;TROIANO, Leonarda;NEMES, Elisa;PINTI, Marcello;LUGLI, Enrico;CONSOLO, Ugo;BALLI, Fiorella;COSSARIZZA, Andrea
2007

Abstract

Different types of cells from subjects with Down syndrome (DS) have an increased susceptibility to cell death. We have studied apoptosis and mitochondrial (mt) membrane potential (Delta Psi(m)) in peripheral blood mononuclear cells (PBMC) from DS children and age-matched healthy donors after in vitro treatment with apoptogenic molecules, along with mtDNA content. We found that PBMC from DS and healthy controls had a similar tendency to undergo apoptosis and a similar amount of mtDNA. However, in cells from DS subjects, mitochondria showed a higher loss of Delta Psi(m), underlying the presence of an increasing susceptibility of these organelles to damaging agents. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
2007
581
3
521
525
Mitochondrial alterations and tendency to apoptosis in peripheral blood cells from children with Down syndrome / Roat, Erika; Prada, Nicole; Ferraresi, Roberta; Giovenzana, Chiara; Nasi, Milena; Troiano, Leonarda; Nemes, Elisa; Pinti, Marcello; Lugli, Enrico; O., Biagioni; M., Mariotti; L., Ciacci; Consolo, Ugo; Balli, Fiorella; Cossarizza, Andrea. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 581:3(2007), pp. 521-525. [10.1016/j.febslet.2006.12.058]
Roat, Erika; Prada, Nicole; Ferraresi, Roberta; Giovenzana, Chiara; Nasi, Milena; Troiano, Leonarda; Nemes, Elisa; Pinti, Marcello; Lugli, Enrico; O.,...espandi
File in questo prodotto:
File Dimensione Formato  
Lavoro 2 - 1-s2.0-S0014579307000415-main.pdf

Accesso riservato

Tipologia: Altro
Dimensione 281.51 kB
Formato Adobe PDF
281.51 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/612603
Citazioni
  • ???jsp.display-item.citation.pmc??? 16
  • Scopus 37
  • ???jsp.display-item.citation.isi??? 35
social impact