Background and aim: Little is known of hepatitis C virus ( HCV) genotypes in HCV infected children. This retrospective, multicentre study investigated genotype distribution and correlation with clinical features and outcome in a large series of Italian children. Methods: Between 1990 and 2002, 373 HCV RNA positive children, consecutively recruited in 15 centres, were assayed for genotypes by a commercial line probe assay. Results: The following genotype distribution pattern was recorded: genotype 1b = 41%; 1a = 20%; 2 = 17%; 3 = 14.5%; 4 = 5%; other = 2.5%. The prevalence of genotypes 1b and 2 decreased significantly ( p< 0.001) among children born from 1990 onwards compared with older children ( 46% v 70%) while the rate of genotypes 3 and 4 increased significantly ( from 8% to 30%). Children infected with genotype 3 had the highest alanine aminotransferase levels and the highest rate of spontaneous viraemia clearance within the first three years of life ( 32% v 3% in children with genotype 1; p< 0.001). Of 96 children enrolled in interferon trials during the survey, 22% definitely lost HCV RNA, including 57% of those with genotypes 2 and 3. Conclusion: HCV genotypes 1 and 2 are still prevalent among infected adolescents and young adults in Italy but rates of infection with genotypes 3 and 4 are rapidly increasing among children. These changes could modify the clinical pattern of hepatitis C in forthcoming years as children infected with genotype 3 have the best chance of spontaneous viraemia clearance early in life, and respond to interferon in a high proportion of cases.

Hepatitis C virus (HCV) genotypes in 373 Italian children with HCV infection: changing distribution and correlation with clinical features and outcome / Bortolotti, F; Resti, M; Marcellini, M; Giacchino, R; Verucchi, G; Nebbia, G; Zancan, L; Marazzi, Mg; Barbera, C; Maccabruni, A; Zuin, G; Maggiore, G; Balli, Fiorella; Vajro, P; Lepore, L; Molesini, M; Guido, M; Bartolacci, S; Noventa, F.. - In: GUT. - ISSN 0017-5749. - STAMPA. - 54(6):(2005), pp. 852-857.

Hepatitis C virus (HCV) genotypes in 373 Italian children with HCV infection: changing distribution and correlation with clinical features and outcome

BALLI, Fiorella;
2005

Abstract

Background and aim: Little is known of hepatitis C virus ( HCV) genotypes in HCV infected children. This retrospective, multicentre study investigated genotype distribution and correlation with clinical features and outcome in a large series of Italian children. Methods: Between 1990 and 2002, 373 HCV RNA positive children, consecutively recruited in 15 centres, were assayed for genotypes by a commercial line probe assay. Results: The following genotype distribution pattern was recorded: genotype 1b = 41%; 1a = 20%; 2 = 17%; 3 = 14.5%; 4 = 5%; other = 2.5%. The prevalence of genotypes 1b and 2 decreased significantly ( p< 0.001) among children born from 1990 onwards compared with older children ( 46% v 70%) while the rate of genotypes 3 and 4 increased significantly ( from 8% to 30%). Children infected with genotype 3 had the highest alanine aminotransferase levels and the highest rate of spontaneous viraemia clearance within the first three years of life ( 32% v 3% in children with genotype 1; p< 0.001). Of 96 children enrolled in interferon trials during the survey, 22% definitely lost HCV RNA, including 57% of those with genotypes 2 and 3. Conclusion: HCV genotypes 1 and 2 are still prevalent among infected adolescents and young adults in Italy but rates of infection with genotypes 3 and 4 are rapidly increasing among children. These changes could modify the clinical pattern of hepatitis C in forthcoming years as children infected with genotype 3 have the best chance of spontaneous viraemia clearance early in life, and respond to interferon in a high proportion of cases.
GUT
54(6)
852
857
Hepatitis C virus (HCV) genotypes in 373 Italian children with HCV infection: changing distribution and correlation with clinical features and outcome / Bortolotti, F; Resti, M; Marcellini, M; Giacchino, R; Verucchi, G; Nebbia, G; Zancan, L; Marazzi, Mg; Barbera, C; Maccabruni, A; Zuin, G; Maggiore, G; Balli, Fiorella; Vajro, P; Lepore, L; Molesini, M; Guido, M; Bartolacci, S; Noventa, F.. - In: GUT. - ISSN 0017-5749. - STAMPA. - 54(6):(2005), pp. 852-857.
Bortolotti, F; Resti, M; Marcellini, M; Giacchino, R; Verucchi, G; Nebbia, G; Zancan, L; Marazzi, Mg; Barbera, C; Maccabruni, A; Zuin, G; Maggiore, G; Balli, Fiorella; Vajro, P; Lepore, L; Molesini, M; Guido, M; Bartolacci, S; Noventa, F.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/611867
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