The interaction of nano-particles derived from ceramic objects and handicrafts with the human body has been investigated with a particular emphasis to defense mechanisms. Macrophage (professional) and epithelial (non-professional) cells were exposed in vitro to TiO2, SiO2, or ZrO2 nano-particles, and their vitality and inflammatory/immune activation checked. All nano-particles showed effects on cell activation, although different in nature and extent. In particular, SiO2 nano-particles directly induced significant inflammatory activation of macrophages, as judged by production of the inflammatory cytokines IL-1beta and TNF-alpha and TLR modulation. Thus, it is suggested that exposure to ceramic nano-particles can contribute to the induction of inflammation-related pathologies.
Modulation of defense cell functions by nano-particles in vitro / Lucarelli, M; Monari, Emanuela; Gatti, Antonietta; Boraschi, D.. - STAMPA. - 254-256:(2004), pp. 907-910. (Intervento presentato al convegno 16th International Symposium on Ceramics in Medicine tenutosi a Porto, prt nel NOV 06-09, 2003) [10.4028/www.scientific.net/KEM.254-256.907].
Modulation of defense cell functions by nano-particles in vitro
MONARI, Emanuela;GATTI, Antonietta;
2004
Abstract
The interaction of nano-particles derived from ceramic objects and handicrafts with the human body has been investigated with a particular emphasis to defense mechanisms. Macrophage (professional) and epithelial (non-professional) cells were exposed in vitro to TiO2, SiO2, or ZrO2 nano-particles, and their vitality and inflammatory/immune activation checked. All nano-particles showed effects on cell activation, although different in nature and extent. In particular, SiO2 nano-particles directly induced significant inflammatory activation of macrophages, as judged by production of the inflammatory cytokines IL-1beta and TNF-alpha and TLR modulation. Thus, it is suggested that exposure to ceramic nano-particles can contribute to the induction of inflammation-related pathologies.
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
