The interaction of nano-particles derived from ceramic objects and handicrafts with the human body has been investigated with a particular emphasis to defense mechanisms. Macrophage (professional) and epithelial (non-professional) cells were exposed in vitro to TiO2, SiO2, or ZrO2 nano-particles, and their vitality and inflammatory/immune activation checked. All nano-particles showed effects on cell activation, although different in nature and extent. In particular, SiO2 nano-particles directly induced significant inflammatory activation of macrophages, as judged by production of the inflammatory cytokines IL-1beta and TNF-alpha and TLR modulation. Thus, it is suggested that exposure to ceramic nano-particles can contribute to the induction of inflammation-related pathologies.
Modulation of defense cell functions by nano-particles in vitro / Lucarelli, M; Monari, Emanuela; Gatti, Antonietta; Boraschi, D.. - STAMPA. - 254-2(2004), pp. 907-910. ((Intervento presentato al convegno 16th International Symposium on Ceramics in Medicine tenutosi a Oporto, PORTUGAL nel NOV 06-09, 2003.
Data di pubblicazione: | 2004 |
Titolo: | Modulation of defense cell functions by nano-particles in vitro |
Autore/i: | Lucarelli, M; Monari, Emanuela; Gatti, Antonietta; Boraschi, D. |
Autore/i UNIMORE: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.4028/www.scientific.net/KEM.254-256.907 |
Codice identificativo Scopus: | 2-s2.0-0347516115 |
Codice identificativo ISI: | WOS:000189415000224 |
Nome del convegno: | 16th International Symposium on Ceramics in Medicine |
Luogo del convegno: | Oporto, PORTUGAL |
Data del convegno: | NOV 06-09, 2003 |
Volume: | 254-2 |
Pagina iniziale: | 907 |
Pagina finale: | 910 |
Citazione: | Modulation of defense cell functions by nano-particles in vitro / Lucarelli, M; Monari, Emanuela; Gatti, Antonietta; Boraschi, D.. - STAMPA. - 254-2(2004), pp. 907-910. ((Intervento presentato al convegno 16th International Symposium on Ceramics in Medicine tenutosi a Oporto, PORTUGAL nel NOV 06-09, 2003. |
Tipologia | Relazione in Atti di Convegno |
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