1. Toluene diisocyanate produced concentration-dependent contractions of the rat isolated urinary bladder. 2. The contractions were tetrodotoxin-resistant and were abolished by previous exposure of the strips to capsaicin. 3. Indomethacin (5 microM) and ruthenium red (30 microM) inhibited toluene diisocyanate-induced contractions. Responses expressed as a percentage of the response obtained with substance P, 30 nM, were respectively 141.6 +/- 24.8% and 20.1 +/- 5.1% in control and indomethacin-treated strips (P less than 0.005); 123.0 +/- 30.2% and 14.0 +/- 6.5% in control and ruthenium red-treated strips (0.01 less than P less than 0.05). 4. These results suggest that toluene diisocyanate-induced contractions of the rat isolated bladder are the result of the release of cyclo-oxygenase products which may act by activating the capsaicin receptor.
Pharmacological modulation of the contractile response to toluene diisocyanate in the rat isolated urinary bladder / C. E., Mapp; P., Chitano; Fabbri, Leonardo; R., Patacchini; C. A., Maggi. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - STAMPA. - 100(1990), pp. 886-888.
Data di pubblicazione: | 1990 |
Titolo: | Pharmacological modulation of the contractile response to toluene diisocyanate in the rat isolated urinary bladder. |
Autore/i: | C. E., Mapp; P., Chitano; Fabbri, Leonardo; R., Patacchini; C. A., Maggi |
Autore/i UNIMORE: | |
Rivista: | |
Volume: | 100 |
Pagina iniziale: | 886 |
Pagina finale: | 888 |
Codice identificativo ISI: | WOS:A1990DQ01800038 |
Codice identificativo Scopus: | 2-s2.0-0025321084 |
Codice identificativo Pubmed: | 1698499 |
Citazione: | Pharmacological modulation of the contractile response to toluene diisocyanate in the rat isolated urinary bladder / C. E., Mapp; P., Chitano; Fabbri, Leonardo; R., Patacchini; C. A., Maggi. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - STAMPA. - 100(1990), pp. 886-888. |
Tipologia | Articolo su rivista |
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