The newly synthesized triazole, 1-amino-6-methyl-4-phenylpyrazolo [3,4-d]-1,2,3-triazole (V5), was tested on the dermatophyte Trichophyton rubrum. Optical and electron microscopy showed that the treatment suppressed the various forms of saprophytic conidia, induced the formation of resistant spores (chlamidospores) and accelerated the formation of parasitic conidia (arthroconidia). In conclusion, this new triazole did not reveal any fungistatic or fungicidal activity and could not be considered as an antifungal substance. On the contrary, it stimulated the development of resistant and parasitic forms of spores.
Alterations in spore productions in Trichophyton rubrum treated “in vitro” with 1-amino-6-methyl-4-phenylpyrazolo-[3,4-d]-1,2,3,triazole / Mares, D; Romagnoli, Carlo; Sacchetti, G; Vicentini, C. B. AND BRUNI A.. - In: MYCOSES. - ISSN 0933-7407. - STAMPA. - 42:(1999), pp. 549-554.
Alterations in spore productions in Trichophyton rubrum treated “in vitro” with 1-amino-6-methyl-4-phenylpyrazolo-[3,4-d]-1,2,3,triazole
ROMAGNOLI, Carlo;
1999
Abstract
The newly synthesized triazole, 1-amino-6-methyl-4-phenylpyrazolo [3,4-d]-1,2,3-triazole (V5), was tested on the dermatophyte Trichophyton rubrum. Optical and electron microscopy showed that the treatment suppressed the various forms of saprophytic conidia, induced the formation of resistant spores (chlamidospores) and accelerated the formation of parasitic conidia (arthroconidia). In conclusion, this new triazole did not reveal any fungistatic or fungicidal activity and could not be considered as an antifungal substance. On the contrary, it stimulated the development of resistant and parasitic forms of spores.
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