Antifungal  activity of some 2,2':5',2" terthiophene derivatives

MARES, D.; ROMAGNOLI, Carlo; ROSSI, R.; CARPITA, A.; BRUNI, M. CIOFALO AND A.

The dermatophyte Microsporum cookei Ajello was treated with nine new natural and synthetic 2,2':5',2"-terthiophenes to determine their possible antifungal activity. In the dark the thiophenes were inactive, while when photoactivated with UV-A they induced a remarkable reduction in the growth rate of the fungus. The only exception was (E)-N-(2-methylpropyl)-3-(2,2':5',2"-terthien-5-yl)-propenamide , which was not fungistatic even at the highest dose tested (24 microM). The more active compounds were 3'-methoxy-2,2':5',2"-terthiophene and 3'-methylthio-2,2':5',2"-terthiophene, whose activity seems to be related to the presence of a substituent in the 3' position of the central ring of thiophenes. Transmission electron microscopic observations demonstrated the photoactive nature of the synthetic molecules to be similar to that of alpha-terthienyl, a natural thiophene present in some Asteraceae. The dark treatment caused only the accumulation of the compound in vacuoles, without other evident alterations. After UV-A irradiation the activated thiophene causes severe modifications to the endomembrane system, probably via oxygen-dependent mechanism.

Data di pubblicazione:	1994
Titolo:	Antifungal activity of some 2,2':5',2" terthiophene derivatives
Autore/i:	D., Mares; Romagnoli, Carlo; R., Rossi; A., Carpita; M. CIOFALO AND A., Bruni
Autore/i UNIMORE:	D. MARES ROMAGNOLI, Carlo R. ROSSI A. CARPITA M. CIOFALO AND A. BRUNI mostra contributor esterni nascondi contributor esterni
Rivista:	MYCOSES
Volume:	37
Pagina iniziale:	377
Pagina finale:	383
Codice identificativo ISI:	WOS:A1994QN78400014
Codice identificativo Scopus:	2-s2.0-0028610571
Codice identificativo Pubmed:	7746300
Citazione:	Antifungal activity of some 2,2':5',2" terthiophene derivatives / D., Mares; Romagnoli, Carlo; R., Rossi; A., Carpita; M. CIOFALO AND A., Bruni. - In: MYCOSES. - ISSN 0933-7407. - STAMPA. - 37(1994), pp. 377-383.
Tipologia	Articolo su rivista

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http://hdl.handle.net/11380/585532

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