The dermatophyte Microsporum cookei Ajello was treated with nine new natural and synthetic 2,2':5',2"-terthiophenes to determine their possible antifungal activity. In the dark the thiophenes were inactive, while when photoactivated with UV-A they induced a remarkable reduction in the growth rate of the fungus. The only exception was (E)-N-(2-methylpropyl)-3-(2,2':5',2"-terthien-5-yl)-propenamide , which was not fungistatic even at the highest dose tested (24 microM). The more active compounds were 3'-methoxy-2,2':5',2"-terthiophene and 3'-methylthio-2,2':5',2"-terthiophene, whose activity seems to be related to the presence of a substituent in the 3' position of the central ring of thiophenes. Transmission electron microscopic observations demonstrated the photoactive nature of the synthetic molecules to be similar to that of alpha-terthienyl, a natural thiophene present in some Asteraceae. The dark treatment caused only the accumulation of the compound in vacuoles, without other evident alterations. After UV-A irradiation the activated thiophene causes severe modifications to the endomembrane system, probably via oxygen-dependent mechanism.
Antifungal activity of some 2,2':5',2" terthiophene derivatives / D., Mares; Romagnoli, Carlo; R., Rossi; A., Carpita; M. CIOFALO AND A., Bruni. - In: MYCOSES. - ISSN 0933-7407. - STAMPA. - 37(1994), pp. 377-383.
Data di pubblicazione: | 1994 | |
Titolo: | Antifungal activity of some 2,2':5',2" terthiophene derivatives | |
Autore/i: | D., Mares; Romagnoli, Carlo; R., Rossi; A., Carpita; M. CIOFALO AND A., Bruni | |
Autore/i UNIMORE: | ||
Rivista: | ||
Volume: | 37 | |
Pagina iniziale: | 377 | |
Pagina finale: | 383 | |
Codice identificativo ISI: | WOS:A1994QN78400014 | |
Codice identificativo Scopus: | 2-s2.0-0028610571 | |
Codice identificativo Pubmed: | 7746300 | |
Citazione: | Antifungal activity of some 2,2':5',2" terthiophene derivatives / D., Mares; Romagnoli, Carlo; R., Rossi; A., Carpita; M. CIOFALO AND A., Bruni. - In: MYCOSES. - ISSN 0933-7407. - STAMPA. - 37(1994), pp. 377-383. | |
Tipologia | Articolo su rivista |
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