Migraine is a common and disabling neurological disease of unknown origin characterized by a remarkable clinical variability. It shows strong familial aggregation, suggesting that genetic factors are involved in its pathogenesis. Different approaches have been used to elucidate this hereditary component, but a unique transmission model and causative gene(s) have not yet been identified. We report clinical and molecular data from a large Italian pedigree in which migraine without aura (MO) segregates as an autosomal dominant trait. After exclusion of any association between MO and the known familial hemiplegic migraine and migraine with aura loci, we performed a genomewide linkage analysis using 482 polymorphic microsatellite markers. We obtained significant evidence of linkage between the MO phenotype and the marker D14S978 on 14q22.1 (maximum two-point LOD score of 3.70, at a recombination fraction of 0.01). Multipoint parametric analysis (maximum LOD score of 5.25 between markers D14S976 and D14S978) and haplotype construction showed strong evidence of linkage in a region of 10 cM flanked by markers D14S1027 and D14S980 on chromosome 14q21.2-q22.3. These results indicate the first evidence of a genetic locus associated with MO on chromosome 14.

A locus for migraine without aura maps on chromosome 14q21.2- q22.3 / D., Soragna; A., Vettori; G., Carraro; Marchioni, . E.; G., Vazza; S., Bellini; Tupler, Rossella; F. SAVOLDI, M. L. MOSTACCIUOLO. - In: AMERICAN JOURNAL OF HUMAN GENETICS. - ISSN 0002-9297. - STAMPA. - 72:1(2003), pp. 161-167. [10.1086/345298]

A locus for migraine without aura maps on chromosome 14q21.2- q22.3.

TUPLER, Rossella;
2003

Abstract

Migraine is a common and disabling neurological disease of unknown origin characterized by a remarkable clinical variability. It shows strong familial aggregation, suggesting that genetic factors are involved in its pathogenesis. Different approaches have been used to elucidate this hereditary component, but a unique transmission model and causative gene(s) have not yet been identified. We report clinical and molecular data from a large Italian pedigree in which migraine without aura (MO) segregates as an autosomal dominant trait. After exclusion of any association between MO and the known familial hemiplegic migraine and migraine with aura loci, we performed a genomewide linkage analysis using 482 polymorphic microsatellite markers. We obtained significant evidence of linkage between the MO phenotype and the marker D14S978 on 14q22.1 (maximum two-point LOD score of 3.70, at a recombination fraction of 0.01). Multipoint parametric analysis (maximum LOD score of 5.25 between markers D14S976 and D14S978) and haplotype construction showed strong evidence of linkage in a region of 10 cM flanked by markers D14S1027 and D14S980 on chromosome 14q21.2-q22.3. These results indicate the first evidence of a genetic locus associated with MO on chromosome 14.
2003
72
1
161
167
A locus for migraine without aura maps on chromosome 14q21.2- q22.3 / D., Soragna; A., Vettori; G., Carraro; Marchioni, . E.; G., Vazza; S., Bellini; Tupler, Rossella; F. SAVOLDI, M. L. MOSTACCIUOLO. - In: AMERICAN JOURNAL OF HUMAN GENETICS. - ISSN 0002-9297. - STAMPA. - 72:1(2003), pp. 161-167. [10.1086/345298]
D., Soragna; A., Vettori; G., Carraro; Marchioni, . E.; G., Vazza; S., Bellini; Tupler, Rossella; F. SAVOLDI, M. L. MOSTACCIUOLO
File in questo prodotto:
File Dimensione Formato  
PIIS000292970760514X.pdf

Open access

Tipologia: Versione pubblicata dall'editore
Dimensione 804.05 kB
Formato Adobe PDF
804.05 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/459476
Citazioni
  • ???jsp.display-item.citation.pmc??? 15
  • Scopus 84
  • ???jsp.display-item.citation.isi??? 68
social impact