In continuing our search in the benzothiadiazine field, we have synthesized new alkylated 2,1,3-BTD and 1,2,4-BTD derivatives. The procedure of alkylation is led via Mitsunobu reaction with good yields. The compounds were tested for their antiviral activity versus some viral strain (ADV, HHV-6, Cox-B5 and H-CMV) and most of them are resulted active at micromolar level. Except compound 1a that presents a high cytotoxicity (maximum non toxic concentration was 3μM), all the other molecules prepared are poorly cytotoxic (maximum non toxic concentrations were >25μM).
Synthesis and antiviral activity of new benzothiadiazine dioxide derivates / Tait, Annalisa; Luppi, Amedeo; Cermelli, Claudio. - In: JOURNAL OF HETEROCYCLIC CHEMISTRY. - ISSN 0022-152X. - STAMPA. - 41:5(2004), pp. 747-753. [10.1002/jhet.5570410516]
Synthesis and antiviral activity of new benzothiadiazine dioxide derivates
TAIT, Annalisa;LUPPI, Amedeo;CERMELLI, Claudio
2004
Abstract
In continuing our search in the benzothiadiazine field, we have synthesized new alkylated 2,1,3-BTD and 1,2,4-BTD derivatives. The procedure of alkylation is led via Mitsunobu reaction with good yields. The compounds were tested for their antiviral activity versus some viral strain (ADV, HHV-6, Cox-B5 and H-CMV) and most of them are resulted active at micromolar level. Except compound 1a that presents a high cytotoxicity (maximum non toxic concentration was 3μM), all the other molecules prepared are poorly cytotoxic (maximum non toxic concentrations were >25μM).
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
