AbstractObjectives To assess the risk of fetal loss attributable to second trimester amniocentesis in singleton pregnancies through a cross-sectional study. Methods Records of 5043 consecutive second trimester amniocentesis, performed by a single operator between 1997 and 2003, were analyzed. Fetal loss post amniocentesis was calculated by grouping pregnant women in age classes and assessing observed/expected (O/E) rate. Results Total fetal losses were 40 (0.81%): 33 cases (0.67%) occurred before the 24th week, 37 cases (0.76%) before the 28th gestational week, and 3 cases (0.06%) after the 28th week of pregnancy. An age-dependent increase of the rate of fetal loss, not statistically significant (Chi-Square = 0.349, p = 0.505) was observed. The total O/E ratio values did not show any statistically significant risk (O/E ratio = 1.25, Cl = 0.86-1.64). The analysis of the single age classes did not detect any statistical significance. The excess fetal loss rate associated with amniocentesis was 0.16%. Conclusions No effect of the 2nd trimester amniocentesis was noted on fetal loss.

Age-specific risk of fetal loss post second trimester amniocentesis: analysis of 5043 cases / V., Mazza; M., Pati; Bertucci, Emma; C., Re; A., Ranzi; Percesepe, Antonio; Forabosco, Antonino; Volpe, Annibale. - In: PRENATAL DIAGNOSIS. - ISSN 0197-3851. - STAMPA. - 27:2(2007), pp. 180-183. [10.1002/pd.1647]

Age-specific risk of fetal loss post second trimester amniocentesis: analysis of 5043 cases

BERTUCCI, Emma;PERCESEPE, Antonio;FORABOSCO, Antonino;VOLPE, Annibale
2007

Abstract

AbstractObjectives To assess the risk of fetal loss attributable to second trimester amniocentesis in singleton pregnancies through a cross-sectional study. Methods Records of 5043 consecutive second trimester amniocentesis, performed by a single operator between 1997 and 2003, were analyzed. Fetal loss post amniocentesis was calculated by grouping pregnant women in age classes and assessing observed/expected (O/E) rate. Results Total fetal losses were 40 (0.81%): 33 cases (0.67%) occurred before the 24th week, 37 cases (0.76%) before the 28th gestational week, and 3 cases (0.06%) after the 28th week of pregnancy. An age-dependent increase of the rate of fetal loss, not statistically significant (Chi-Square = 0.349, p = 0.505) was observed. The total O/E ratio values did not show any statistically significant risk (O/E ratio = 1.25, Cl = 0.86-1.64). The analysis of the single age classes did not detect any statistical significance. The excess fetal loss rate associated with amniocentesis was 0.16%. Conclusions No effect of the 2nd trimester amniocentesis was noted on fetal loss.
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Age-specific risk of fetal loss post second trimester amniocentesis: analysis of 5043 cases / V., Mazza; M., Pati; Bertucci, Emma; C., Re; A., Ranzi; Percesepe, Antonio; Forabosco, Antonino; Volpe, Annibale. - In: PRENATAL DIAGNOSIS. - ISSN 0197-3851. - STAMPA. - 27:2(2007), pp. 180-183. [10.1002/pd.1647]
V., Mazza; M., Pati; Bertucci, Emma; C., Re; A., Ranzi; Percesepe, Antonio; Forabosco, Antonino; Volpe, Annibale
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/310704
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