The reaction of N-substituted 4-methyl-2-pyrrolidinones or 4-diethoxyphosphoryl analogues, carrying at least two chlorine atoms between the C(3) and C(6) carbons, with alkaline methoxide in methanol afforded the corresponding 5-methoxylated 3-pyrrolin-2-ones, useful adducts for the preparation of agrochemicals or medicinal compounds. (C) 2003 Elsevier Science Ltd. All rights reserved.
Synthesis of 5-methoxylated 3-pyrrolin-2-one via the rearrangement of chlorinated pyrrolidin-2-ones / Ghelfi, Franco; Cv, Stevens; I., Laureyn; E., Van Meenen; Tm, Rogge; L., De Buyck; K. V., Nikitin; Grandi, Romano; Libertini, Emanuela; Pagnoni, Ugo Maria; Schenetti, Luisa. - In: TETRAHEDRON. - ISSN 0040-4020. - STAMPA. - 59:8(2003), pp. 1147-1157. [10.1016/S0040-4020(03)00044-9]
Synthesis of 5-methoxylated 3-pyrrolin-2-one via the rearrangement of chlorinated pyrrolidin-2-ones
GHELFI, Franco;GRANDI, Romano;LIBERTINI, Emanuela;PAGNONI, Ugo Maria;SCHENETTI, Luisa
2003
Abstract
The reaction of N-substituted 4-methyl-2-pyrrolidinones or 4-diethoxyphosphoryl analogues, carrying at least two chlorine atoms between the C(3) and C(6) carbons, with alkaline methoxide in methanol afforded the corresponding 5-methoxylated 3-pyrrolin-2-ones, useful adducts for the preparation of agrochemicals or medicinal compounds. (C) 2003 Elsevier Science Ltd. All rights reserved.
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