The presence of polyamines is required for the apoptotic program triggered by a-deoxy-D-ribose (dRib) in HL-60 cells, but their oxidative metabolites does not appear to be involved in the oxidative stress caused by the sugar. The present study points to a relationship between spermidine-induced G(1) to S phase transition and the onset of dRib-induced apoptosis. Conversely, the G(1) block induced by alpha-difluoromethylornithine (DFMO) is associated with a protective effect against dRib-induced cell suicide. Replenishment of the intracellular spermidine pool by exogenous putrescine and spermidine induces cell cycle progression and restores apoptotic levels. The present data indicate that the induction of cell cycle progression by spermidine is a condition facilitating the activation of the apoptotic process by dRib.

2-Deoxy-D-ribose-induced apoptosis in HL-60 cells is associated with the cell cycle progression by spermidine / Monti, Maria Giuseppina; S., Ghiaroni; D., Barbieri; C., Franceschi; Marverti, Gaetano; Moruzzi, Maria Stella. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - STAMPA. - 257:(1999), pp. 460-465.

2-Deoxy-D-ribose-induced apoptosis in HL-60 cells is associated with the cell cycle progression by spermidine

MONTI, Maria Giuseppina;MARVERTI, Gaetano;MORUZZI, Maria Stella
1999-01-01

Abstract

The presence of polyamines is required for the apoptotic program triggered by a-deoxy-D-ribose (dRib) in HL-60 cells, but their oxidative metabolites does not appear to be involved in the oxidative stress caused by the sugar. The present study points to a relationship between spermidine-induced G(1) to S phase transition and the onset of dRib-induced apoptosis. Conversely, the G(1) block induced by alpha-difluoromethylornithine (DFMO) is associated with a protective effect against dRib-induced cell suicide. Replenishment of the intracellular spermidine pool by exogenous putrescine and spermidine induces cell cycle progression and restores apoptotic levels. The present data indicate that the induction of cell cycle progression by spermidine is a condition facilitating the activation of the apoptotic process by dRib.
257
460
465
2-Deoxy-D-ribose-induced apoptosis in HL-60 cells is associated with the cell cycle progression by spermidine / Monti, Maria Giuseppina; S., Ghiaroni; D., Barbieri; C., Franceschi; Marverti, Gaetano; Moruzzi, Maria Stella. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - STAMPA. - 257:(1999), pp. 460-465.
Monti, Maria Giuseppina; S., Ghiaroni; D., Barbieri; C., Franceschi; Marverti, Gaetano; Moruzzi, Maria Stella
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/310547
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