Levodropropizine, an antitussive drug, was prepared in high enantiomeric excess in three steps, starting from dichloroacetone (2).Monosubstitution of 2 with sodium benzoate and subsequent baker’s yeast reduction stereoselectively afforded the correspondingchlorohydrin in 73% ee, which was converted to levodropropizine and enantiomerically enriched up to 95% ee by fractionalcrystallisation
Chemo-enzymatic synthesis of levodropropizine / Caselli, Emilia; Tosi, Giovanni; Forni, Arrigo; Bucciarelli, Maria; Prati, Fabio. - In: IL FARMACO. - ISSN 0014-827X. - STAMPA. - 58:(2003), pp. 1029-1032.
Chemo-enzymatic synthesis of levodropropizine
CASELLI, Emilia;TOSI, Giovanni;FORNI, Arrigo;BUCCIARELLI, Maria;PRATI, Fabio
2003
Abstract
Levodropropizine, an antitussive drug, was prepared in high enantiomeric excess in three steps, starting from dichloroacetone (2).Monosubstitution of 2 with sodium benzoate and subsequent baker’s yeast reduction stereoselectively afforded the correspondingchlorohydrin in 73% ee, which was converted to levodropropizine and enantiomerically enriched up to 95% ee by fractionalcrystallisation
| File | Dimensione | Formato | |
|---|---|---|---|
|
Il Farmaco 2003.pdf
non disponibili
Tipologia:
Post-print dell'autore (bozza post referaggio)
Dimensione
177.19 kB
Formato
Adobe PDF
|
177.19 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
