Coronary heart disease is a prevalent condition and a leading cause of death in developed countries. Most cases are due to the cluster of classical risk factors, such as smoking, diabetes, high blood pressure and dyslipidaemia. However, a few patients develop severe and premature arteriosclerosis in spite of absence of common risk factors. Here, we present the clinical, analytical and molecular features of a 36-years-old man who died from advanced ischaemic heart disease as a result of cerebrotendinous xanthomatosis (CTX), a rare condition characterized by elevation in plasma and most tissues of cholestanol and where neurological impairment is the hallmark of this disease. We discuss the relevance of heart disease and the mechanism leading to accelerate arteriosclerosis is CTX.

Coronary heart disease in a patient with cerebrotendinous xanthomatosis / P., Valdivielso; CALANDRA BUONAURA, Sebastiano; Jc, Duran; Garuti, Rita; E., Herrera; P., Gonzalez. - In: JOURNAL OF INTERNAL MEDICINE. - ISSN 0954-6820. - STAMPA. - 255:(2004), pp. 680-683.

Coronary heart disease in a patient with cerebrotendinous xanthomatosis

CALANDRA BUONAURA, Sebastiano;GARUTI, Rita;
2004

Abstract

Coronary heart disease is a prevalent condition and a leading cause of death in developed countries. Most cases are due to the cluster of classical risk factors, such as smoking, diabetes, high blood pressure and dyslipidaemia. However, a few patients develop severe and premature arteriosclerosis in spite of absence of common risk factors. Here, we present the clinical, analytical and molecular features of a 36-years-old man who died from advanced ischaemic heart disease as a result of cerebrotendinous xanthomatosis (CTX), a rare condition characterized by elevation in plasma and most tissues of cholestanol and where neurological impairment is the hallmark of this disease. We discuss the relevance of heart disease and the mechanism leading to accelerate arteriosclerosis is CTX.
255
680
683
Coronary heart disease in a patient with cerebrotendinous xanthomatosis / P., Valdivielso; CALANDRA BUONAURA, Sebastiano; Jc, Duran; Garuti, Rita; E., Herrera; P., Gonzalez. - In: JOURNAL OF INTERNAL MEDICINE. - ISSN 0954-6820. - STAMPA. - 255:(2004), pp. 680-683.
P., Valdivielso; CALANDRA BUONAURA, Sebastiano; Jc, Duran; Garuti, Rita; E., Herrera; P., Gonzalez
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/306843
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