Purpose: To evaluate the longitudinal anatomical response of retinal-choroidal anastomosis (RCA) to intravitreal ranibizumab injection using spectral-domain optical coherence tomography (SD-OCT). Methods: We reviewed the medical records of 21 consecutive patients with RCA who underwent intravitreal ranibizumab injections at the University Eye Clinic of Creteil between January 2009 and June 2010. The SD-OCT features at baseline, at 3 months, and at 12 months were retrospectively analyzed. Based on SD-OCT, RCAs were classified as showing a focal retinal pigment epithelium (RPE) erosion ("erosion sign'') over a small, localized RPE elevation; a focal RPE break leaving two free RPE flaps ("flap sign'') at the level of a small, localized RPE elevation; or a large convex RPE prominence and a focal funnel-shaped RPE kissing an inverted focal funnel-shaped inner neuroepithelium ("kissing sign''). Results: Twenty-one eyes of 21 patients (3 men and 18 women, aged 81.6 +/- 6.8 years) diagnosed with RCA naive to any treatment were included for analysis. Spearman rho correlation between best-corrected visual acuity and lesion classification was 0.54 (P = 0.01) at Month 3 and 0.85 (P < 0.001) at Month 12. Eyes showing the flap sign at baseline underwent significantly less ranibizumab injections after the loading phase (2.14 +/- 0.89 vs. 3.40 +/- 0.96, P = 0.007) and showed a greater improvement in best-corrected visual acuity at Month 12 (from 0.52 +/- 0.14 to 0.38 +/- 0.15, P = 0.03) compared with eyes showing the kissing sign. At 12 months, 3 of 10 eyes with flap sign at baseline showed RCA activity, whereas 7 of 10 regressed to erosion sign phase. Of the 10 eyes with kissing sign at baseline, 6 progressed to a fibroglial scar. Conclusion: A flap sign of RCA at baseline seems a favorable prognostic factor as concerns best-corrected visual acuity improvement and the need for retreatment. RETINA 32: 458-467, 2012
LONGITUDINAL ANATOMICAL RESPONSE OF RETINAL-CHOROIDAL ANASTOMOSIS TO ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY / Querques, G., Rousseau, A., Forte, R., Scemama, C., Caillaux, V., Querques, L., Souied, E.h.. - In: RETINA. - ISSN 0275-004X. - 32:3(2012), pp. 458-467. [10.1097/IAE.0b013e3182205960]
LONGITUDINAL ANATOMICAL RESPONSE OF RETINAL-CHOROIDAL ANASTOMOSIS TO ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY
QUERQUES , GIUSEPPE;
2012
Abstract
Purpose: To evaluate the longitudinal anatomical response of retinal-choroidal anastomosis (RCA) to intravitreal ranibizumab injection using spectral-domain optical coherence tomography (SD-OCT). Methods: We reviewed the medical records of 21 consecutive patients with RCA who underwent intravitreal ranibizumab injections at the University Eye Clinic of Creteil between January 2009 and June 2010. The SD-OCT features at baseline, at 3 months, and at 12 months were retrospectively analyzed. Based on SD-OCT, RCAs were classified as showing a focal retinal pigment epithelium (RPE) erosion ("erosion sign'') over a small, localized RPE elevation; a focal RPE break leaving two free RPE flaps ("flap sign'') at the level of a small, localized RPE elevation; or a large convex RPE prominence and a focal funnel-shaped RPE kissing an inverted focal funnel-shaped inner neuroepithelium ("kissing sign''). Results: Twenty-one eyes of 21 patients (3 men and 18 women, aged 81.6 +/- 6.8 years) diagnosed with RCA naive to any treatment were included for analysis. Spearman rho correlation between best-corrected visual acuity and lesion classification was 0.54 (P = 0.01) at Month 3 and 0.85 (P < 0.001) at Month 12. Eyes showing the flap sign at baseline underwent significantly less ranibizumab injections after the loading phase (2.14 +/- 0.89 vs. 3.40 +/- 0.96, P = 0.007) and showed a greater improvement in best-corrected visual acuity at Month 12 (from 0.52 +/- 0.14 to 0.38 +/- 0.15, P = 0.03) compared with eyes showing the kissing sign. At 12 months, 3 of 10 eyes with flap sign at baseline showed RCA activity, whereas 7 of 10 regressed to erosion sign phase. Of the 10 eyes with kissing sign at baseline, 6 progressed to a fibroglial scar. Conclusion: A flap sign of RCA at baseline seems a favorable prognostic factor as concerns best-corrected visual acuity improvement and the need for retreatment. RETINA 32: 458-467, 2012
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
