A combined theoretical and experimental study on the carbonylation of glycerol with urea has identified low operating pressure as a key parameter for process optimization. Based on these insights, an improved multiple-pass continuous-flow system was developed, enabling the solvent-free synthesis of glycerol carbonate (GC) with enhanced efficiency. The optimized process achieved a productivity of ∼130 g/day, delivering high purity (>95%), and an isolated yield of 80%, thereby demonstrating the viability of this approach for sustainable GC production.
Continuous-Flow Glycerolysis of Urea to Glycerol Carbonate: The Critical Role of Operating Pressure / Severini, A., Anderlini, B., Lezza, A., Burello, M., Porcelli, N., Mazzali, M., D'Eusanio, V., Rivi, M., Fontanesi, C., Roncaglia, F.. - In: INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH. - ISSN 0888-5885. - 64:38(2025), pp. 18630-18639. [10.1021/acs.iecr.5c02554]
Continuous-Flow Glycerolysis of Urea to Glycerol Carbonate: The Critical Role of Operating Pressure
Severini, Andrea;Anderlini, Biagio;Lezza, Antonio;Burello, Marianna;Porcelli, Nicola;Mazzali, Marco;D'Eusanio, Veronica;Rivi, Mirco;Fontanesi, Claudio;Roncaglia, Fabrizio
2025
Abstract
A combined theoretical and experimental study on the carbonylation of glycerol with urea has identified low operating pressure as a key parameter for process optimization. Based on these insights, an improved multiple-pass continuous-flow system was developed, enabling the solvent-free synthesis of glycerol carbonate (GC) with enhanced efficiency. The optimized process achieved a productivity of ∼130 g/day, delivering high purity (>95%), and an isolated yield of 80%, thereby demonstrating the viability of this approach for sustainable GC production.
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