Light isacrucial tool inmedicinefordiagnosisand treatment.Newlight sourcescalledorganic light-emittingdevices (OLEDs) have been integratedwith various extracorporeal and implantabledevicestosenseorstimulatespecificcellularresponses. However, oneof thecurrent challenges remaining is todesigna transientOLEDthat functionseffectivelyandcompletelydissolves inside the human bodywhen it is no longer needed, without affectinghomeostasis.Thisworkaddresses this issuebycreating thefirst transientchitosan-basedOLED.TheOLEDis turnedon at lowvoltages andemits abright green lightwithamaximum luminanceof36cd/m2. Invitroassaysshowedthatall layersbreak downunder physiological settings, and thebiocompatibilitywas confirmedbyinvivotests.Thechitosan-basedOLEDrepresentsa breakthroughintransientelectronicsandadvances implantable light-basedbiomedical applications
Light is a crucial tool in medicine for diagnosis and treatment. New light sources called organic light-emitting devices (OLEDs) have been integrated with various extracorporeal and implantable devices to sense or stimulate specific cellular responses. However, one of the current challenges remaining is to design a transient OLED that functions effectively and completely dissolves inside the human body when it is no longer needed, without affecting homeostasis. This work addresses this issue by creating the first transient chitosan-based OLED. The OLED is turned on at low voltages and emits a bright green light with a maximum luminance of 36 cd/m2. In vitro assays showed that all layers break down under physiological settings, and the biocompatibility was confirmed by in vivo tests. The chitosan-based OLED represents a breakthrough in transient electronics and advances implantable light-based biomedical applications.
DevelopmentofaBiodegradableGreenEmitterChitosan-Based OLEDfor ImplantableBiomedicalDevices / Pires, F., Daini, E., Vandini, E., Giuliani, D., Vilella, A., Ferreira, F.c., Morgado, J.. - In: ACS APPLIED MATERIALS & INTERFACES. - ISSN 1944-8252. - 17:26(2025), pp. 37510-37522. [10.1021/acsami.5c05499]
DevelopmentofaBiodegradableGreenEmitterChitosan-Based OLEDfor ImplantableBiomedicalDevices
Daini E;Vandini E;Giuliani D;Vilella A;
2025
Abstract
Light is a crucial tool in medicine for diagnosis and treatment. New light sources called organic light-emitting devices (OLEDs) have been integrated with various extracorporeal and implantable devices to sense or stimulate specific cellular responses. However, one of the current challenges remaining is to design a transient OLED that functions effectively and completely dissolves inside the human body when it is no longer needed, without affecting homeostasis. This work addresses this issue by creating the first transient chitosan-based OLED. The OLED is turned on at low voltages and emits a bright green light with a maximum luminance of 36 cd/m2. In vitro assays showed that all layers break down under physiological settings, and the biocompatibility was confirmed by in vivo tests. The chitosan-based OLED represents a breakthrough in transient electronics and advances implantable light-based biomedical applications.
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