Older people with HIV (PWH) may benefit from long-acting cabotegravir/rilpivirine (LA-CAB/RPV), a population underrepresented in trials and observational cohorts. In the GEPPO cohort, 135 PWH >65 years of age received bimonthly LA-CAB/RPV. After 17.4 months, virological suppression (HIV-RNA <50 copies/mL) was maintained in all, while 15 participants discontinued them (11.1%, 10% in the first 12 months): 1 participant with isolated HbCAb at baseline showed a late HBV reactivation (19.4 months after starting). These findings support LA-CAB/RPV's efficacy and tolerability in older PWH.
Bimonthly Administered Long-Acting Cabotegravir and Rilpivirine Are Highly Effective and Well-Tolerated in People With Human Immunodeficiency Virus Above 65 Years / Calcagno, A., Candela, C., Riva, A., Calza, S., Fioretti, B., Gardini, S., Milic, J., Celesia, B.M., Orofino, G., De Vito, A., De Socio, G.V., Cossu, M.V., Barrera, F., Mazzitelli, M., Nozza, S., Guaraldi, G., Focà, E., Null, N., Arsuffi, S., Azzolino, D., et al.. - In: OPEN FORUM INFECTIOUS DISEASES. - ISSN 2328-8957. - 13:1(2026), pp. 1-3. [10.1093/ofid/ofaf817]
Bimonthly Administered Long-Acting Cabotegravir and Rilpivirine Are Highly Effective and Well-Tolerated in People With Human Immunodeficiency Virus Above 65 Years
Milic, Jovana;Guaraldi, Giovanni;Guaraldi, Giovanni;Mussi, Chiara;
2026
Abstract
Older people with HIV (PWH) may benefit from long-acting cabotegravir/rilpivirine (LA-CAB/RPV), a population underrepresented in trials and observational cohorts. In the GEPPO cohort, 135 PWH >65 years of age received bimonthly LA-CAB/RPV. After 17.4 months, virological suppression (HIV-RNA <50 copies/mL) was maintained in all, while 15 participants discontinued them (11.1%, 10% in the first 12 months): 1 participant with isolated HbCAb at baseline showed a late HBV reactivation (19.4 months after starting). These findings support LA-CAB/RPV's efficacy and tolerability in older PWH.
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