Glioblastoma (GBM) remains a deadly tumor. Treatment with chemo-radiotherapy and corticosteroids is known to impair the functionality of lymphocytes, potentially compromising the development of autologous CAR T cell therapies. We here generated pre-clinical investigations of autologous anti-GD2 CAR T cells tested against 2D and 3D models of GBM primary cells. We detected a robust antitumor effect, highlighting the feasibility of developing an autologous anti-GD2 CAR T cell-based therapy for GBM patients.
Autologous anti-GD2 CAR T cells efficiently target primary human glioblastoma / Chiavelli, C., Prapa, M., Rovesti, G., Silingardi, M., Neri, G., Pugliese, G., Trudu, L., Dall'Ora, M., Golinelli, G., Grisendi, G., Vinet, J., Bestagno, M., Spano, C., Papapietro, R.V., Depenni, R., Di Emidio, K., Pasetto, A., Nascimento Silva, D., Feletti, A., Berlucchi, S., et al.. - In: NPJ PRECISION ONCOLOGY. - ISSN 2397-768X. - 8:1(2024), pp. 1-9. [10.1038/s41698-024-00506-z]
Autologous anti-GD2 CAR T cells efficiently target primary human glioblastoma
Chiavelli C.;Prapa M.;Rovesti G.;Silingardi M.;Neri G.;Pugliese G.;Trudu L.;Dall'Ora M.;Golinelli G.;Grisendi G.;Vinet J.;Spano C.;Depenni R.;Di Emidio K.;Pasetto A.;Iaccarino C.;Pavesi G.;Dominici M.
2024
Abstract
Glioblastoma (GBM) remains a deadly tumor. Treatment with chemo-radiotherapy and corticosteroids is known to impair the functionality of lymphocytes, potentially compromising the development of autologous CAR T cell therapies. We here generated pre-clinical investigations of autologous anti-GD2 CAR T cells tested against 2D and 3D models of GBM primary cells. We detected a robust antitumor effect, highlighting the feasibility of developing an autologous anti-GD2 CAR T cell-based therapy for GBM patients.
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