We aimed to determine risk factors for thrombotic events in early/prefibrotic myelofibrosis diagnosed according to the World Health Organization criteria. Multivariate Cox regression analysis was calculated on a total number of 264 patients derived from an international database. After a median follow-up of 6.28 years, 42 (15.9%) patients experienced arterial (n = 31) or venous thrombosis (n = 11). A higher leukocyte count correlated with an increased risk for total thrombosis and in particular, with an increased risk for arterial thrombosis (P = 0.005, HR 1.15 and P = 0.047, HR 1.12, respectively). A platelet count above 870 x 10(9)/L was associated with a lower risk for total thrombosis and also for venous thrombosis (P = 0.022, HR 0.44 and P = 0.027, HR 0.19). Moreover, a lower hemoglobin level was associated with an increased risk for venous thrombosis (P = 0.007, HR 0.59). Our data indicate that leukocytosis is a prominent risk factor for thrombosis in early/prefibrotic MF.

Leukocytosis as an important risk factor for arterial thrombosis in WHO-defined early/prefibrotic myelofibrosis: an international study of 264 patients / Buxhofer-Ausch, V; Gisslinger, H; Thiele, J; Gisslinger, B; Kvasnicka, Hm; Mullauer, L; Frantal, S; Carobbio, A; Passamonti, F; Rumi, E; Ruggeri, M; Rodeghiero, F; Randi, Ml; Bertozzi, I; Vannucchi, Am; Antonioli, E; Finazzi, G; Gangat, N; Tefferi, A; Barbui, T. - In: AMERICAN JOURNAL OF HEMATOLOGY. - ISSN 1096-8652. - 87:7(2012), pp. 669-672. [10.1002/ajh.23217]

Leukocytosis as an important risk factor for arterial thrombosis in WHO-defined early/prefibrotic myelofibrosis: an international study of 264 patients

Carobbio A;
2012

Abstract

We aimed to determine risk factors for thrombotic events in early/prefibrotic myelofibrosis diagnosed according to the World Health Organization criteria. Multivariate Cox regression analysis was calculated on a total number of 264 patients derived from an international database. After a median follow-up of 6.28 years, 42 (15.9%) patients experienced arterial (n = 31) or venous thrombosis (n = 11). A higher leukocyte count correlated with an increased risk for total thrombosis and in particular, with an increased risk for arterial thrombosis (P = 0.005, HR 1.15 and P = 0.047, HR 1.12, respectively). A platelet count above 870 x 10(9)/L was associated with a lower risk for total thrombosis and also for venous thrombosis (P = 0.022, HR 0.44 and P = 0.027, HR 0.19). Moreover, a lower hemoglobin level was associated with an increased risk for venous thrombosis (P = 0.007, HR 0.59). Our data indicate that leukocytosis is a prominent risk factor for thrombosis in early/prefibrotic MF.
2012
87
7
669
672
Leukocytosis as an important risk factor for arterial thrombosis in WHO-defined early/prefibrotic myelofibrosis: an international study of 264 patients / Buxhofer-Ausch, V; Gisslinger, H; Thiele, J; Gisslinger, B; Kvasnicka, Hm; Mullauer, L; Frantal, S; Carobbio, A; Passamonti, F; Rumi, E; Ruggeri, M; Rodeghiero, F; Randi, Ml; Bertozzi, I; Vannucchi, Am; Antonioli, E; Finazzi, G; Gangat, N; Tefferi, A; Barbui, T. - In: AMERICAN JOURNAL OF HEMATOLOGY. - ISSN 1096-8652. - 87:7(2012), pp. 669-672. [10.1002/ajh.23217]
Buxhofer-Ausch, V; Gisslinger, H; Thiele, J; Gisslinger, B; Kvasnicka, Hm; Mullauer, L; Frantal, S; Carobbio, A; Passamonti, F; Rumi, E; Ruggeri, M; Rodeghiero, F; Randi, Ml; Bertozzi, I; Vannucchi, Am; Antonioli, E; Finazzi, G; Gangat, N; Tefferi, A; Barbui, T
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1331662
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