The role of signal transduction in cancer progression is well established and actively studied, including in osteosarcoma. The signal transduction pathways involved in the regulation of calcium metabolism are being intensively studied, with particular regard to phosphoinositide-specific phospholipase C (PLC) signaling. This family of enzymes helps to modulate calcium metabolism and is interconnected with additional signaling molecules belonging to different pathways. The expression and subcellular localization of PLCs have been shown to differ in normal cells compared to their neoplastic counterpart in different types of cancer. We now describe the localization of the PLC enzyme family in 4 human osteosarcoma cells different in origin and malignancy (MG63, U2OS, HOS and 143B cell lines). We identified cell line-specific differences and discussed possible meaning and implications.
Specific subcellular localization of phosphoinositide-specific phospholipase C enzymes in different human osteosarcoma cell lines / Corradini, M; Checchi, M; Benincasa, M; Ferretti, M; Cavani, F; Palumbo, C; LO VASCO, VINCENZA RITA. - In: JOURNAL OF CELLULAR SIGNALING. - ISSN 2692-0638. - 5:1(2024), pp. 1-9. [10.33696/Signaling.5.107]
Specific subcellular localization of phosphoinositide-specific phospholipase C enzymes in different human osteosarcoma cell lines
Corradini MInvestigation
;Checchi MMembro del Collaboration Group
;Benincasa MMembro del Collaboration Group
;Ferretti MMembro del Collaboration Group
;Cavani FMembro del Collaboration Group
;Palumbo CMembro del Collaboration Group
;Lo Vasco VR
Writing – Original Draft Preparation
2024
Abstract
The role of signal transduction in cancer progression is well established and actively studied, including in osteosarcoma. The signal transduction pathways involved in the regulation of calcium metabolism are being intensively studied, with particular regard to phosphoinositide-specific phospholipase C (PLC) signaling. This family of enzymes helps to modulate calcium metabolism and is interconnected with additional signaling molecules belonging to different pathways. The expression and subcellular localization of PLCs have been shown to differ in normal cells compared to their neoplastic counterpart in different types of cancer. We now describe the localization of the PLC enzyme family in 4 human osteosarcoma cells different in origin and malignancy (MG63, U2OS, HOS and 143B cell lines). We identified cell line-specific differences and discussed possible meaning and implications.File | Dimensione | Formato | |
---|---|---|---|
article-pdf-1706525371-1111.pdf
Open access
Tipologia:
Versione pubblicata dall'editore
Dimensione
714.33 kB
Formato
Adobe PDF
|
714.33 kB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris