Although cells decommission embryonic enhancers by erasing histone marks, these regions retain hypomethylated DNA into adulthood, preserving an accurate archive of tissue-specific developmental cis elements. This epigenetic memory is recovered after prolonged absence of polycomb repressive complex 2, when transcription factors selectively reactivate hypomethylated developmental enhancers and their tissue-restricted target genes.
Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA / Jadhav, U.; Cavazza, A.; Banerjee, K. K.; Xie, H.; O'Neill, N. K.; Saenz-Vash, V.; Herbert, Z.; Madha, S.; Orkin, S. H.; Zhai, H.; Shivdasani, R. A.. - In: MOLECULAR CELL. - ISSN 1097-2765. - 74:3(2019), pp. 542-554.e5. [10.1016/j.molcel.2019.02.024]
Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA
Cavazza A.;
2019
Abstract
Although cells decommission embryonic enhancers by erasing histone marks, these regions retain hypomethylated DNA into adulthood, preserving an accurate archive of tissue-specific developmental cis elements. This epigenetic memory is recovered after prolonged absence of polycomb repressive complex 2, when transcription factors selectively reactivate hypomethylated developmental enhancers and their tissue-restricted target genes.
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