Manganese (Mn) is an essential metal that can become neurotoxic at elevated levels with negative consequences on neurodevelopment. We have evaluated the influence of single nucleotide polymorphisms (SNPs) in Mn transporter genes SLC30A10 and SLC39A8 on Mn concentrations in dentine, a validated biomarker that reflects Mn tissue concentrations early in life.
Polymorphisms in manganese transporters show developmental stage and sex specific associations with manganese concentrations in primary teeth / Wahlberg, Karin; Arora, Manish; Curtin, Austen; Curtin, Paul; Wright, Robert O; Smith, Donald R; Lucchini, Roberto; Broberg, Karin; Austin, Christine. - In: NEUROTOXICOLOGY. - ISSN 0161-813X. - (2017). [10.1016/j.neuro.2017.09.003]