Skin often represents a target organ for adverse drug reactions and this also applies to the mRNA vaccines against Sars-CoV-2. Here we present a case of extensive livedoid reaction after 2nd dose of BNT162b-2 vaccine with massive blood skin extravasation and no systemic symptoms apart from anemization. The 30-year-old woman developed progressively enlarging livedoid lesions on limbs and abdomen. Histology showed a near-normal epidermis and a very mild interstitial mixed inflammatory infiltrate with extensive blood extravasation in mid- and deep dermis. Diagnosis was adverse reaction to vaccine with skin capillary hyperpermeability and anaemization with lower than diagnostic features of cutaneous small vessel vasculitis. To date, no cases of a livedoid skin reaction associated to Covid-19 vaccine have been reported, and this case illustrates that massive livedoid reaction can be another kind of skin reaction to mRNA Covid-19 vaccine.

Livedoid skin reaction to 2nd dose of mRNA Covid-19 vaccine / Girolami, Ilaria; Eisendle, Klaus; Kluge, Reinhard Walther; Hanspeter, Esther; Eccher, Albino; Vizziello, Leonardo; Zampieri, Pierfrancesco; Mazzoleni, Guido. - In: PATHOLOGICA. - ISSN 1591-951X. - 114:4(2022), pp. 322-325. [10.32074/1591-951X-746]

Livedoid skin reaction to 2nd dose of mRNA Covid-19 vaccine

Eccher, Albino;
2022

Abstract

Skin often represents a target organ for adverse drug reactions and this also applies to the mRNA vaccines against Sars-CoV-2. Here we present a case of extensive livedoid reaction after 2nd dose of BNT162b-2 vaccine with massive blood skin extravasation and no systemic symptoms apart from anemization. The 30-year-old woman developed progressively enlarging livedoid lesions on limbs and abdomen. Histology showed a near-normal epidermis and a very mild interstitial mixed inflammatory infiltrate with extensive blood extravasation in mid- and deep dermis. Diagnosis was adverse reaction to vaccine with skin capillary hyperpermeability and anaemization with lower than diagnostic features of cutaneous small vessel vasculitis. To date, no cases of a livedoid skin reaction associated to Covid-19 vaccine have been reported, and this case illustrates that massive livedoid reaction can be another kind of skin reaction to mRNA Covid-19 vaccine.
2022
114
4
322
325
Livedoid skin reaction to 2nd dose of mRNA Covid-19 vaccine / Girolami, Ilaria; Eisendle, Klaus; Kluge, Reinhard Walther; Hanspeter, Esther; Eccher, Albino; Vizziello, Leonardo; Zampieri, Pierfrancesco; Mazzoleni, Guido. - In: PATHOLOGICA. - ISSN 1591-951X. - 114:4(2022), pp. 322-325. [10.32074/1591-951X-746]
Girolami, Ilaria; Eisendle, Klaus; Kluge, Reinhard Walther; Hanspeter, Esther; Eccher, Albino; Vizziello, Leonardo; Zampieri, Pierfrancesco; Mazzoleni, Guido
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1317438
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