: Long noncoding RNAs (lncRNAs) are emerging as powerful and versatile regulators of transcriptional programs and distinctive biomarkers of T-cell Lymphoma progression disease. Their role in the aggressive ALK- Anaplastic Large Cell Lymphoma (ALCL) subtype has been only in part elucidated. Starting from our previously identified ALCL-associated lncRNA signature and performing digital gene expression profiling of a retrospective cohort of ALCLs, we defined an 11 lncRNA signature able to discriminate among ALCL subtypes. We selected a not previously characterized lncRNA, MTAAT, with an ALK- ALCL preferential expression, for molecular and functional studies. We demonstrated that lncRNA MTAAT contributes to an aberrant mitochondrial turnover restraining mitophagy and promoting cellular proliferation. Functionally, lncRNA MTAAT acts as a repressor of a set of genes related to mitochondria quality control via chromatin reorganization. Collectively, our work demonstrates the transcriptional role of lncRNA MTAAT in orchestrating a complex transcriptional program sustaining ALK- ALCL progression.

Long non-coding RNA mitophagy and ALK-negative anaplastic lymphoma-associated transcript: a novel regulator of mitophagy in T-cell lymphoma / Mularoni, Valentina; Donati, Benedetta; Tameni, Annalisa; Manicardi, Veronica; Reggiani, Francesca; Sauta, Elisabetta; Zanelli, Magda; Tigano, Marco; Vitale, Emanuele; Torricelli, Federica; Ascani, Stefano; Martino, Giovanni; Inghirami, Giorgio; Sanguedolce, Francesca; Ruffini, Alessia; Bavieri, Alberto; Luminari, Stefano; Pizzi, Marco; Dei Tos, Angelo Paolo; Fesce, Cinzia; Neri, Antonino; Ciarrocchi, Alessia; Fragliasso, Valentina. - In: HAEMATOLOGICA. - ISSN 1592-8721. - 108:12(2023), pp. 3333-3346. [10.3324/haematol.2022.282552]

Long non-coding RNA mitophagy and ALK-negative anaplastic lymphoma-associated transcript: a novel regulator of mitophagy in T-cell lymphoma

Mularoni, Valentina;Tameni, Annalisa;Manicardi, Veronica;Vitale, Emanuele;Bavieri, Alberto;Luminari, Stefano;Fragliasso, Valentina
2023

Abstract

: Long noncoding RNAs (lncRNAs) are emerging as powerful and versatile regulators of transcriptional programs and distinctive biomarkers of T-cell Lymphoma progression disease. Their role in the aggressive ALK- Anaplastic Large Cell Lymphoma (ALCL) subtype has been only in part elucidated. Starting from our previously identified ALCL-associated lncRNA signature and performing digital gene expression profiling of a retrospective cohort of ALCLs, we defined an 11 lncRNA signature able to discriminate among ALCL subtypes. We selected a not previously characterized lncRNA, MTAAT, with an ALK- ALCL preferential expression, for molecular and functional studies. We demonstrated that lncRNA MTAAT contributes to an aberrant mitochondrial turnover restraining mitophagy and promoting cellular proliferation. Functionally, lncRNA MTAAT acts as a repressor of a set of genes related to mitochondria quality control via chromatin reorganization. Collectively, our work demonstrates the transcriptional role of lncRNA MTAAT in orchestrating a complex transcriptional program sustaining ALK- ALCL progression.
2023
108
12
3333
3346
Long non-coding RNA mitophagy and ALK-negative anaplastic lymphoma-associated transcript: a novel regulator of mitophagy in T-cell lymphoma / Mularoni, Valentina; Donati, Benedetta; Tameni, Annalisa; Manicardi, Veronica; Reggiani, Francesca; Sauta, Elisabetta; Zanelli, Magda; Tigano, Marco; Vitale, Emanuele; Torricelli, Federica; Ascani, Stefano; Martino, Giovanni; Inghirami, Giorgio; Sanguedolce, Francesca; Ruffini, Alessia; Bavieri, Alberto; Luminari, Stefano; Pizzi, Marco; Dei Tos, Angelo Paolo; Fesce, Cinzia; Neri, Antonino; Ciarrocchi, Alessia; Fragliasso, Valentina. - In: HAEMATOLOGICA. - ISSN 1592-8721. - 108:12(2023), pp. 3333-3346. [10.3324/haematol.2022.282552]
Mularoni, Valentina; Donati, Benedetta; Tameni, Annalisa; Manicardi, Veronica; Reggiani, Francesca; Sauta, Elisabetta; Zanelli, Magda; Tigano, Marco; ...espandi
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