To investigate a possible animal reservoir of Helicobacter pylori, 15 pigs, 15 rabbits and 5 cows slaughtered for consumption were studied. Raised serum IgG levels were found in 93% of the pigs and 87% of the rabbits, but levels were normal in the cattle. In the controlled testings three of 22 humans had elevated IgG to H pylori and in all three H pylori was detected by the use of monoclonal antibody. Helicobacter pylori were identified in gastric brushings by a monoclonal antibody in 8 out of 10 pigs and 7 out of 10 rabbits. This study suggests an animal reservoir of Helicobacter pylori which may be of importance in human infection.
Detection of helicobacter pylori-like organisms in the stomach of some food-source animals using a monoclonal antibody / Vaira, D.; Ferron, P.; Negrini, R.; Cavazzini, L.; Holton, J.; Ainley, C.; Londei, M.; Vergura, M.; Rosanna, D.; Colecchia, A.; Taylor, D.; Pieracci, F.; Nenci, I.; Gandolfi, L.; Barbara, L.. - In: ITALIAN JOURNAL OF GASTROENTEROLOGY. - ISSN 0392-0623. - 24:4(1992), pp. 181-184.
Detection of helicobacter pylori-like organisms in the stomach of some food-source animals using a monoclonal antibody
Cavazzini L.;Colecchia A.;
1992
Abstract
To investigate a possible animal reservoir of Helicobacter pylori, 15 pigs, 15 rabbits and 5 cows slaughtered for consumption were studied. Raised serum IgG levels were found in 93% of the pigs and 87% of the rabbits, but levels were normal in the cattle. In the controlled testings three of 22 humans had elevated IgG to H pylori and in all three H pylori was detected by the use of monoclonal antibody. Helicobacter pylori were identified in gastric brushings by a monoclonal antibody in 8 out of 10 pigs and 7 out of 10 rabbits. This study suggests an animal reservoir of Helicobacter pylori which may be of importance in human infection.
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