Women at high inherited risk of ovarian cancer are offered risk-reducing salpingo-oophorectomy (RRSO) from age 35 to 45 years. Although potentially life-saving, RRSO may induce symptoms that negatively affect quality of life and impair long-term health. Clinical care following RRSO is often suboptimal. This scoping review describes how RRSO affects short- and long-term health and provides evidence-based international consensus recommendations for care from preoperative counselling to long-term disease prevention. This includes the efficacy and safety of hormonal and non-hormonal treatments for vasomotor symptoms, sleep disturbance and sexual dysfunction and effective approaches to prevent bone and cardiovascular disease.
Care after premenopausal risk-reducing salpingo-oophorectomy in high-risk women: Scoping review and international consensus recommendations / Nebgen, Denise R; Domchek, Susan M; Kotsopoulos, Joanne; de Hullu, Joanne A; Crosbie, Emma J; Paramanandam, Vincent Singh; Brood-van Zanten, Monique M A; Norquist, Barbara M; Guise, Theresa; Rozenberg, Serge; Kurian, Allison W; Pederson, Holly J; Yuksel, Nese; Michaelson-Cohen, Rachel; Bober, Sharon L; da Silva Filho, Agnaldo Lopes; Johansen, Nora; Guidozzi, F; Evans, D Gareth; Menon, Usha; Kingsberg, Sheryl A; Powell, C Bethan; Grandi, Giovanni; Marchetti, Claudia; Jacobson, Michelle; Brennan, Donal J; Hickey, Martha. - In: BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY. - ISSN 1470-0328. - 130:12(2023), pp. 1437-1450. [10.1111/1471-0528.17511]
Care after premenopausal risk-reducing salpingo-oophorectomy in high-risk women: Scoping review and international consensus recommendations
Grandi, Giovanni;
2023
Abstract
Women at high inherited risk of ovarian cancer are offered risk-reducing salpingo-oophorectomy (RRSO) from age 35 to 45 years. Although potentially life-saving, RRSO may induce symptoms that negatively affect quality of life and impair long-term health. Clinical care following RRSO is often suboptimal. This scoping review describes how RRSO affects short- and long-term health and provides evidence-based international consensus recommendations for care from preoperative counselling to long-term disease prevention. This includes the efficacy and safety of hormonal and non-hormonal treatments for vasomotor symptoms, sleep disturbance and sexual dysfunction and effective approaches to prevent bone and cardiovascular disease.
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