Women at high inherited risk of ovarian cancer are offered risk-reducing salpingo-oophorectomy (RRSO) from age 35 to 45 years. Although potentially life-saving, RRSO may induce symptoms that negatively affect quality of life and impair long-term health. Clinical care following RRSO is often suboptimal. This scoping review describes how RRSO affects short- and long-term health and provides evidence-based international consensus recommendations for care from preoperative counselling to long-term disease prevention. This includes the efficacy and safety of hormonal and non-hormonal treatments for vasomotor symptoms, sleep disturbance and sexual dysfunction and effective approaches to prevent bone and cardiovascular disease.
Care after premenopausal risk-reducing salpingo-oophorectomy in high-risk women: Scoping review and international consensus recommendations / Nebgen, D.R., Domchek, S.M., Kotsopoulos, J., De Hullu, J.A., Crosbie, E.J., Paramanandam, V.S., Brood-van Zanten, M.M.A., Norquist, B.M., Guise, T., Rozenberg, S., Kurian, A.W., Pederson, H.J., Yuksel, N., Michaelson-Cohen, R., Bober, S.L., Da Silva Filho, A.L., Johansen, N., Guidozzi, F., Evans, D.G., Menon, U., et al.. - In: BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY. - ISSN 1470-0328. - 130:12(2023), pp. 1437-1450. [10.1111/1471-0528.17511]
Care after premenopausal risk-reducing salpingo-oophorectomy in high-risk women: Scoping review and international consensus recommendations
Grandi, Giovanni;
2023
Abstract
Women at high inherited risk of ovarian cancer are offered risk-reducing salpingo-oophorectomy (RRSO) from age 35 to 45 years. Although potentially life-saving, RRSO may induce symptoms that negatively affect quality of life and impair long-term health. Clinical care following RRSO is often suboptimal. This scoping review describes how RRSO affects short- and long-term health and provides evidence-based international consensus recommendations for care from preoperative counselling to long-term disease prevention. This includes the efficacy and safety of hormonal and non-hormonal treatments for vasomotor symptoms, sleep disturbance and sexual dysfunction and effective approaches to prevent bone and cardiovascular disease.
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BJOG - 2023 - Nebgen - Care after premenopausal risk‐reducing salpingo‐oophorectomy in high‐risk women Scoping review and.pdf
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