Purpose: People with hematologic malignancies have a significantly higher risk of developing severe and protracted forms of SARS-CoV-2 infection compared to immunocompetent patients, regardless of vaccination status. Results: We describe two cases of prolonged SARS-CoV-2 infection with multiple relapses of COVID-19 pneumonia in patients with follicular lymphoma treated with bendamustine and obinutuzumab or rituximab. The aim is to highlight the complexity of SARS-CoV-2 infection in this fragile group of patients and the necessity of evidence-based strategies to treat them properly. Conclusions: Patients with hematological malignancies treated with bendamustine and anti-CD20 antibodies had a significant risk of prolonged and relapsing course of COVID-19. Specific preventive and therapeutic strategies should be developed for this group of patients.
Persistent SARS-CoV-2 infection with multiple clinical relapses in two patients with follicular lymphoma treated with bendamustine and obinutuzumab or rituximab / Franceschini, Erica; Pellegrino, Mariachiara; Todisco, Vera; Dolci, Giovanni; Bettelli, Francesca; Meschiari, Marianna; Bedini, Andrea; Fregni-Serpini, Giulia; Grottola, Antonella; Guaraldi, Giovanni; Pecorari, Monica; Sarti, Mario; Luppi, Mario; Perno, Carlo Federico; Mussini, Cristina. - In: INFECTION. - ISSN 0300-8126. - 51:5(2023), pp. 1577-1581. [10.1007/s15010-023-02039-2]
Persistent SARS-CoV-2 infection with multiple clinical relapses in two patients with follicular lymphoma treated with bendamustine and obinutuzumab or rituximab
Franceschini, Erica;Pellegrino, Mariachiara;Todisco, Vera;Dolci, Giovanni;Bettelli, Francesca;Meschiari, Marianna;Grottola, Antonella;Guaraldi, Giovanni;Luppi, Mario;Mussini, Cristina
2023
Abstract
Purpose: People with hematologic malignancies have a significantly higher risk of developing severe and protracted forms of SARS-CoV-2 infection compared to immunocompetent patients, regardless of vaccination status. Results: We describe two cases of prolonged SARS-CoV-2 infection with multiple relapses of COVID-19 pneumonia in patients with follicular lymphoma treated with bendamustine and obinutuzumab or rituximab. The aim is to highlight the complexity of SARS-CoV-2 infection in this fragile group of patients and the necessity of evidence-based strategies to treat them properly. Conclusions: Patients with hematological malignancies treated with bendamustine and anti-CD20 antibodies had a significant risk of prolonged and relapsing course of COVID-19. Specific preventive and therapeutic strategies should be developed for this group of patients.
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