Bisphenol A (BPA) is one of the so-called endocrine disrupting chemicals (EDCs) and is thought to be involved in the pathogenesis of different morbid conditions: immune-mediated disorders, type-2 diabetes mellitus, cardiovascular diseases, and cancer. The purpose of this review is to analyze the mechanism of action of bisphenol A, with a special focus on mesenchymal stromal/stem cells (MSCs) and adipogenesis. Its uses will be assessed in various fields: dental, orthopedic, and industrial. The different pathological or physiological conditions altered by BPA and the related molecular pathways will be taken into consideration.
Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions / Della Rocca, Ylenia; Traini, Enrico Matteo; Diomede, Francesca; Fonticoli, Luigia; Trubiani, Oriana; Paganelli, Alessia; Pizzicannella, Jacopo; Marconi, Guya Diletta. - In: PHARMACEUTICS. - ISSN 1999-4923. - 15:3(2023), pp. 908-908. [10.3390/pharmaceutics15030908]
Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions
Paganelli, Alessia
;
2023
Abstract
Bisphenol A (BPA) is one of the so-called endocrine disrupting chemicals (EDCs) and is thought to be involved in the pathogenesis of different morbid conditions: immune-mediated disorders, type-2 diabetes mellitus, cardiovascular diseases, and cancer. The purpose of this review is to analyze the mechanism of action of bisphenol A, with a special focus on mesenchymal stromal/stem cells (MSCs) and adipogenesis. Its uses will be assessed in various fields: dental, orthopedic, and industrial. The different pathological or physiological conditions altered by BPA and the related molecular pathways will be taken into consideration.
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