We report two cases of invasive zygomycoses occurring in severely immunocompromised patients with haematological malignancies that were successfully treated with liposomal amphotericin B and surgical debridement, followed by oral administration of posaconazole. These cases demonstrated that an early instituted, aggressive and combined therapeutic approach results in a recovery from invasive fungal infection, without any relapse of infection, thanks to secondary prophylaxis using posaconazole. © 2009 Blackwell Verlag GmbH.
Efficacy of combined surgery and antifungal therapies for the management of invasive zygomycoses in patients with haematological malignancies / Valentini, C. G.; Candoni, A.; Fianchi, L.; Posteraro, B.; Simeone, E.; Costa, F.; Sanguinetti, M.; Voso, M. T.; Caira, M.; Fanin, R.; Pagano, L.. - In: MYCOSES. - ISSN 0933-7407. - 53:1(2010), pp. 89-92. [10.1111/j.1439-0507.2008.01672.x]