We report two cases of invasive zygomycoses occurring in severely immunocompromised patients with haematological malignancies that were successfully treated with liposomal amphotericin B and surgical debridement, followed by oral administration of posaconazole. These cases demonstrated that an early instituted, aggressive and combined therapeutic approach results in a recovery from invasive fungal infection, without any relapse of infection, thanks to secondary prophylaxis using posaconazole. © 2009 Blackwell Verlag GmbH.
Efficacy of combined surgery and antifungal therapies for the management of invasive zygomycoses in patients with haematological malignancies / Valentini, C.G., Candoni, A., Fianchi, L., Posteraro, B., Simeone, E., Costa, F., Sanguinetti, M., Voso, M.T., Caira, M., Fanin, R., Pagano, L.. - In: MYCOSES. - ISSN 0933-7407. - 53:1(2010), pp. 89-92. [10.1111/j.1439-0507.2008.01672.x]
Efficacy of combined surgery and antifungal therapies for the management of invasive zygomycoses in patients with haematological malignancies
Candoni A.;
2010
Abstract
We report two cases of invasive zygomycoses occurring in severely immunocompromised patients with haematological malignancies that were successfully treated with liposomal amphotericin B and surgical debridement, followed by oral administration of posaconazole. These cases demonstrated that an early instituted, aggressive and combined therapeutic approach results in a recovery from invasive fungal infection, without any relapse of infection, thanks to secondary prophylaxis using posaconazole. © 2009 Blackwell Verlag GmbH.
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