Epilepsy is reported in 29–52% of patients with glioblastoma (GBM) and has an important role in the natural history of this tumor and patients’ life quality. Although GBM is less epileptogenic than lower-grade gliomas, seizures are usually more difficult to control with common antiseizure medications; drug resistance is found in 20% of cases. Recent studies suggest that seizures at the onset of GBM could be a possible favorable independent prognostic factor in patients. Moreover, a growing body of evidence shows that many molecular mechanisms that influence epileptogenesis often regulate GBM growth and invasiveness, sometimes favoring or counteracting the tumor, respectively. The better-characterized players include glutamate, gamma-aminobutyric acid, aquaporin-4, and hypoxia-activated molecules. However, currently available data on the molecular basis of epileptogenesis, tumorigenesis, and their relationship is incomplete or discordant and further research is urgently needed on this topic.

Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship? / Rossi, Jessica; Cavallieri, Francesco; Biagini, Giuseppe; Rizzi, Romana; Russo, Marco; Cozzi, Salvatore; Giaccherini, Lucia; Pisanello, Anna; Valzania, Franco. - In: MEDICINA. - ISSN 1010-660X. - 58:(2022), pp. 1-6. [10.3390/medicina58101349]

Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship?

Jessica Rossi;Francesco Cavallieri
;
Giuseppe Biagini;
2022

Abstract

Epilepsy is reported in 29–52% of patients with glioblastoma (GBM) and has an important role in the natural history of this tumor and patients’ life quality. Although GBM is less epileptogenic than lower-grade gliomas, seizures are usually more difficult to control with common antiseizure medications; drug resistance is found in 20% of cases. Recent studies suggest that seizures at the onset of GBM could be a possible favorable independent prognostic factor in patients. Moreover, a growing body of evidence shows that many molecular mechanisms that influence epileptogenesis often regulate GBM growth and invasiveness, sometimes favoring or counteracting the tumor, respectively. The better-characterized players include glutamate, gamma-aminobutyric acid, aquaporin-4, and hypoxia-activated molecules. However, currently available data on the molecular basis of epileptogenesis, tumorigenesis, and their relationship is incomplete or discordant and further research is urgently needed on this topic.
26-set-2022
58
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6
Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship? / Rossi, Jessica; Cavallieri, Francesco; Biagini, Giuseppe; Rizzi, Romana; Russo, Marco; Cozzi, Salvatore; Giaccherini, Lucia; Pisanello, Anna; Valzania, Franco. - In: MEDICINA. - ISSN 1010-660X. - 58:(2022), pp. 1-6. [10.3390/medicina58101349]
Rossi, Jessica; Cavallieri, Francesco; Biagini, Giuseppe; Rizzi, Romana; Russo, Marco; Cozzi, Salvatore; Giaccherini, Lucia; Pisanello, Anna; Valzania, Franco
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1288100
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