Two groups of 53 subjects (24 healthy volunteers and 29 affected from allergy or suffering with chronic cough or wheezing) were submitted to inhaled metacholine challenge. An appropriate software provided the calculation of FEV1 and sGaw values at single metacholine doses and described 8 parameters through the linear and parabolic regressions (PD20 FEV1 log and par, PD35sGaw log and par, Slope FEV1 and sGaw, Area FEV1 and sGaw). Multiple correlation among parameters and anova analysis revealed a good correlation between linear and parabolic regression values for FEV1 and sGaw and suggested PD35sGaw log as the best parameter to detect responders and non-responders.
Metacholine inhaled challenge and bronchial responsiveness / Clini, E; Colombo, C; Damato, S; Meregalli, G; Tana, F; Allegra, L.. - In: GIORNALE ITALIANO DELLE MALATTIE DEL TORACE. - ISSN 0017-0437. - 45:3(1991), pp. 157-162.
Metacholine inhaled challenge and bronchial responsiveness
Clini E;
1991
Abstract
Two groups of 53 subjects (24 healthy volunteers and 29 affected from allergy or suffering with chronic cough or wheezing) were submitted to inhaled metacholine challenge. An appropriate software provided the calculation of FEV1 and sGaw values at single metacholine doses and described 8 parameters through the linear and parabolic regressions (PD20 FEV1 log and par, PD35sGaw log and par, Slope FEV1 and sGaw, Area FEV1 and sGaw). Multiple correlation among parameters and anova analysis revealed a good correlation between linear and parabolic regression values for FEV1 and sGaw and suggested PD35sGaw log as the best parameter to detect responders and non-responders.
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