Neoplasms with plasma cell differentiation may occasionally involve the skin. Cutaneous lesions may represent the first sign of an underlying systemic plasma cell malignancy, such as multiple myeloma, or the skin itself may be the primary site of occurrence of a hematological tumor with plasma cell differentiation. Starting from examples encountered in our daily practice, we discussed the diagnostic approach pathologists and clinicians should use when faced with cutaneous lesions with plasma cell differentiation. Cases of primary cutaneous marginal zone lymphoma, localized primary amyloidosis/amyloidoma, and cutaneous manifestations (secondary either to multiple myeloma or to plasmablastic lymphoma) are discussed, focusing on the importance of the adequate patient’s work-up and precise clinicopathological correlation to get to the correct diagnosis and appropriate treatment. The pertinent literature has been reviewed, and the clinical presentation, pathological findings, main differential diagnoses, treatment, and outcome of neoplasms with plasma cell differentiation involving the skin are discussed.

Cutaneous Involvement in Diseases with Plasma Cell Differentiation: Diagnostic Approach / Zanelli, M.; Palicelli, A.; Sanguedolce, F.; Zizzo, M.; Filosa, A.; Ricci, L.; Cresta, C.; Martino, G.; Bisagni, A.; Zanetti, E.; Donato, F. D.; Melli, B.; Soriano, A.; Cimino, L.; Cavazza, A.; Vivian, L. F.; Ascani, S.. - In: CURRENT ONCOLOGY. - ISSN 1718-7729. - 29:5(2022), pp. 3026-3043. [10.3390/curroncol29050246]

Cutaneous Involvement in Diseases with Plasma Cell Differentiation: Diagnostic Approach

Zizzo M.;Zanetti E.;Melli B.;Cimino L.;Cavazza A.;
2022

Abstract

Neoplasms with plasma cell differentiation may occasionally involve the skin. Cutaneous lesions may represent the first sign of an underlying systemic plasma cell malignancy, such as multiple myeloma, or the skin itself may be the primary site of occurrence of a hematological tumor with plasma cell differentiation. Starting from examples encountered in our daily practice, we discussed the diagnostic approach pathologists and clinicians should use when faced with cutaneous lesions with plasma cell differentiation. Cases of primary cutaneous marginal zone lymphoma, localized primary amyloidosis/amyloidoma, and cutaneous manifestations (secondary either to multiple myeloma or to plasmablastic lymphoma) are discussed, focusing on the importance of the adequate patient’s work-up and precise clinicopathological correlation to get to the correct diagnosis and appropriate treatment. The pertinent literature has been reviewed, and the clinical presentation, pathological findings, main differential diagnoses, treatment, and outcome of neoplasms with plasma cell differentiation involving the skin are discussed.
2022
29
5
3026
3043
Cutaneous Involvement in Diseases with Plasma Cell Differentiation: Diagnostic Approach / Zanelli, M.; Palicelli, A.; Sanguedolce, F.; Zizzo, M.; Filosa, A.; Ricci, L.; Cresta, C.; Martino, G.; Bisagni, A.; Zanetti, E.; Donato, F. D.; Melli, B.; Soriano, A.; Cimino, L.; Cavazza, A.; Vivian, L. F.; Ascani, S.. - In: CURRENT ONCOLOGY. - ISSN 1718-7729. - 29:5(2022), pp. 3026-3043. [10.3390/curroncol29050246]
Zanelli, M.; Palicelli, A.; Sanguedolce, F.; Zizzo, M.; Filosa, A.; Ricci, L.; Cresta, C.; Martino, G.; Bisagni, A.; Zanetti, E.; Donato, F. D.; Melli...espandi
File in questo prodotto:
File Dimensione Formato  
curroncol-29-00246.pdf

Open access

Tipologia: Versione pubblicata dall'editore
Dimensione 8.74 MB
Formato Adobe PDF
8.74 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1280713
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 1
social impact