Background Hereditary epidermolysis bullosa (EB) is a rare genodermatosis characterized by skin fragility and blistering of the skin and mucous membranes in reaction to minimal traumas. The development of cutaneous squamous cell carcinomas (cSCCs) is one of the most common medical complications in junctional and dystrophic forms of the disease. Complete surgical excision of cutaneous tumors represents the gold standard of treatment. However, not only recognition of cSCCs can be challenging in the affected skin but also wound closure after surgical excision poses a great therapeutic challenge in EB patients. The aim of our study was to analyze the postoperative outcomes of such patients in order to have a better knowledge of the main critical issues in their surgical management and oncological follow-up. Methods We retrospectively identified a cohort of five EB patients treated at Modena University Hospital. Collected data included patient age and sex, date of cSCC diagnosis, relapses/recurrences, site of the neoplasm, number of surgical interventions, use of dermal substitutes, and postoperative infections. Results A total of 26 cSCCs were detected in our cohort. Forty-one surgical interventions were necessary to achieve excision of cSCCs with clear margins, varying from 1 to 4 surgical sessions per cSCC. Dermal substitutes were used in most cases but carried a higher infectious risk. Conclusions EB patients tend to develop numerous cSCCs that often relapse even after complete excision with clear margins. These results stress the importance of early cSCC diagnosis and strict postsurgical follow-up.

Surgical management and oncological follow-up of cutaneous squamous cell carcinomas arising in epidermolysis bullosa patients / Paganelli, Alessia; Giordano, Erminia; Fiorentini, Chiara; Ferrari, Barbara; Reggiani, Camilla; Garbarino, Federico; Magnoni, Cristina. - In: INTERNATIONAL JOURNAL OF DERMATOLOGY. - ISSN 0011-9059. - (2022), pp. Epub ahead of print-ahead of print. [10.1111/ijd.16157]

Surgical management and oncological follow-up of cutaneous squamous cell carcinomas arising in epidermolysis bullosa patients

Paganelli, Alessia
;
Fiorentini, Chiara;Ferrari, Barbara;Reggiani, Camilla;Garbarino, Federico;Magnoni, Cristina
2022

Abstract

Background Hereditary epidermolysis bullosa (EB) is a rare genodermatosis characterized by skin fragility and blistering of the skin and mucous membranes in reaction to minimal traumas. The development of cutaneous squamous cell carcinomas (cSCCs) is one of the most common medical complications in junctional and dystrophic forms of the disease. Complete surgical excision of cutaneous tumors represents the gold standard of treatment. However, not only recognition of cSCCs can be challenging in the affected skin but also wound closure after surgical excision poses a great therapeutic challenge in EB patients. The aim of our study was to analyze the postoperative outcomes of such patients in order to have a better knowledge of the main critical issues in their surgical management and oncological follow-up. Methods We retrospectively identified a cohort of five EB patients treated at Modena University Hospital. Collected data included patient age and sex, date of cSCC diagnosis, relapses/recurrences, site of the neoplasm, number of surgical interventions, use of dermal substitutes, and postoperative infections. Results A total of 26 cSCCs were detected in our cohort. Forty-one surgical interventions were necessary to achieve excision of cSCCs with clear margins, varying from 1 to 4 surgical sessions per cSCC. Dermal substitutes were used in most cases but carried a higher infectious risk. Conclusions EB patients tend to develop numerous cSCCs that often relapse even after complete excision with clear margins. These results stress the importance of early cSCC diagnosis and strict postsurgical follow-up.
22-mar-2022
Epub ahead of print
ahead of print
Surgical management and oncological follow-up of cutaneous squamous cell carcinomas arising in epidermolysis bullosa patients / Paganelli, Alessia; Giordano, Erminia; Fiorentini, Chiara; Ferrari, Barbara; Reggiani, Camilla; Garbarino, Federico; Magnoni, Cristina. - In: INTERNATIONAL JOURNAL OF DERMATOLOGY. - ISSN 0011-9059. - (2022), pp. Epub ahead of print-ahead of print. [10.1111/ijd.16157]
Paganelli, Alessia; Giordano, Erminia; Fiorentini, Chiara; Ferrari, Barbara; Reggiani, Camilla; Garbarino, Federico; Magnoni, Cristina
File in questo prodotto:
File Dimensione Formato  
Int J Dermatology - 2022 - Paganelli - Surgical management and oncological follow%E2%80%90up of cutaneous squamous cell carcinomas-2.pdf

accesso aperto

Tipologia: Versione dell'editore (versione pubblicata)
Dimensione 244.96 kB
Formato Adobe PDF
244.96 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1273557
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact