The purpose of this study was to investigate short-time metabolic variations related to continuous epileptic activity elicited by fixation-off sensitivity (FOS). Time-resolved magnetic resonance spectroscopy was performed on a patient on whom previous clinical findings clearly indicated presence of FOS. The epileptic focus was localized with a simultaneous electroencephalographic and functional magnetic resonance imaging study. The results showed a linear increase of the sum of glutamate and glutamine with time of paroxysmal activity in epileptic focus and much greater concentration of choline-containing compounds in focus than in the contralateral side. © 2006 Elsevier Inc. All rights reserved.
Metabolic alteration transients during paroxysmal activity in an epileptic patient with fixation-off sensitivity: a case study / Giove, Federico; Garreffa, Girolamo; Peca, Stefano; Carní, Marco; Macrì, Maria Antonietta; Di Bonaventura, Carlo; Vaudano, Anna Elisabetta; Giallonardo, Anna Teresa; Prencipe, Massimiliano; Bozzao, Luigi; Pantano, Patrizia; Colonnese, Claudio; Maraviglia, Bruno. - In: MAGNETIC RESONANCE IMAGING. - ISSN 0730-725X. - 24:4(2006), pp. 373-379. [10.1016/j.mri.2005.11.003]
Metabolic alteration transients during paroxysmal activity in an epileptic patient with fixation-off sensitivity: a case study
VAUDANO, Anna Elisabetta;
2006
Abstract
The purpose of this study was to investigate short-time metabolic variations related to continuous epileptic activity elicited by fixation-off sensitivity (FOS). Time-resolved magnetic resonance spectroscopy was performed on a patient on whom previous clinical findings clearly indicated presence of FOS. The epileptic focus was localized with a simultaneous electroencephalographic and functional magnetic resonance imaging study. The results showed a linear increase of the sum of glutamate and glutamine with time of paroxysmal activity in epileptic focus and much greater concentration of choline-containing compounds in focus than in the contralateral side. © 2006 Elsevier Inc. All rights reserved.
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