Purpose: We characterized a family with autosomal dominant lateral temporal epilepsy (ADLTE) whose proband presented uncommon electroclinical findings such as drug-resistant seizures and recurrent episodes of status epilepticus with dysphasic features. Methods: The electroclinical characteristics and LGI1 genotype were defined in the family. In the proband, the ictal pattern was documented during video-EEG monitoring and epileptic activity was mapped by EEG/fMRI. Results: The affected members who were studied had drug-resistant seizures. In the proband, seizures with predominant dysphasic features often occurred as partial status epilepticus. The video-EEG-documented ictal activity and fMRI activation clearly indicated the elective involvement of the left posterior lateral temporal cortex. Sequencing of LGI1 exons revealed a heterozygous c.367G>A mutation in exon 4, resulting in a Glu123Lys substitution in the protein sequence. Conclusions: The uncommon clinical pattern (high seizure frequency, drug-resistance) highlights the variability of the ADLTE phenotype and extends our knowledge of the clinical spectrum associated with LGI1 mutations. © 2009 International League Against Epilepsy.

PURPOSE: We characterized a family with autosomal dominant lateral temporal epilepsy (ADLTE) whose proband presented uncommon electroclinical findings such as drug-resistant seizures and recurrent episodes of status epilepticus with dysphasic features. METHODS: The electroclinical characteristics and LGI1 genotype were defined in the family. In the proband, the ictal pattern was documented during video-EEG monitoring and epileptic activity was mapped by EEG/fMRI. RESULTS: The affected members who were studied had drug-resistant seizures. In the proband, seizures with predominant dysphasic features often occurred as partial status epilepticus. The video-EEG-documented ictal activity and fMRI activation clearly indicated the elective involvement of the left posterior lateral temporal cortex. Sequencing of LGI1 exons revealed a heterozygous c.367GA mutation in exon 4, resulting in a Glu123Lys substitution in the protein sequence. CONCLUSIONS: The uncommon clinical pattern (high seizure frequency, drug-resistance) highlights the variability of the ADLTE phenotype and extends our knowledge of the clinical spectrum associated with LGI1 mutations.

Drug resistant ADLTE and recurrent partial status epilepticus with dysphasic features in a family with a novel LGI1 mutation: electroclinical, genetic, and EEG/fMRI findings / Di Bonaventura, C; Carni, M; Diani, E; Fattouch, Jinane; Vaudano, Anna-Elisabetta; Egeo, G; Pantano, Patrizia; Maraviglia, Bruno; Bozzao, Luigi; Manfredi, Mario; Prencipe, Massimiliano; Giallonardo, Anna Teresa; Nobile, C.. - In: EPILEPSIA. - ISSN 0013-9580. - 50:11(2009), pp. 2481-2486. [10.1111/j.1528-1167.2009.02181.x]

Drug resistant ADLTE and recurrent partial status epilepticus with dysphasic features in a family with a novel LGI1 mutation: electroclinical, genetic, and EEG/fMRI findings

VAUDANO, ANNA-ELISABETTA;
2009

Abstract

PURPOSE: We characterized a family with autosomal dominant lateral temporal epilepsy (ADLTE) whose proband presented uncommon electroclinical findings such as drug-resistant seizures and recurrent episodes of status epilepticus with dysphasic features. METHODS: The electroclinical characteristics and LGI1 genotype were defined in the family. In the proband, the ictal pattern was documented during video-EEG monitoring and epileptic activity was mapped by EEG/fMRI. RESULTS: The affected members who were studied had drug-resistant seizures. In the proband, seizures with predominant dysphasic features often occurred as partial status epilepticus. The video-EEG-documented ictal activity and fMRI activation clearly indicated the elective involvement of the left posterior lateral temporal cortex. Sequencing of LGI1 exons revealed a heterozygous c.367GA mutation in exon 4, resulting in a Glu123Lys substitution in the protein sequence. CONCLUSIONS: The uncommon clinical pattern (high seizure frequency, drug-resistance) highlights the variability of the ADLTE phenotype and extends our knowledge of the clinical spectrum associated with LGI1 mutations.
50
11
2481
2486
Drug resistant ADLTE and recurrent partial status epilepticus with dysphasic features in a family with a novel LGI1 mutation: electroclinical, genetic, and EEG/fMRI findings / Di Bonaventura, C; Carni, M; Diani, E; Fattouch, Jinane; Vaudano, Anna-Elisabetta; Egeo, G; Pantano, Patrizia; Maraviglia, Bruno; Bozzao, Luigi; Manfredi, Mario; Prencipe, Massimiliano; Giallonardo, Anna Teresa; Nobile, C.. - In: EPILEPSIA. - ISSN 0013-9580. - 50:11(2009), pp. 2481-2486. [10.1111/j.1528-1167.2009.02181.x]
DI BONAVENTURA, C; Carni, M; Diani, E; Fattouch, Jinane; Vaudano, ANNA-ELISABETTA; Egeo, G; Pantano, Patrizia; Maraviglia, Bruno; Bozzao, Luigi; Manfredi, Mario; Prencipe, Massimiliano; Giallonardo, Anna Teresa; Nobile, C.
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