Phenotypic features and proliferative ability of thymocytes, splenocytes and peripheral blood lymphocytes of 20-22 weeks human fetuses affected by Down's syndrome (DS) were studied and compared to those of fetuses of the same gestational age with a normal karyotype. In the thymus of both DS and normal fetuses, the great majority of cells was CD1+, CD2+, CD5+, CD4+, CD8+; using double fluorescence analysis, these markers could be detected on the same cell. About 50-60% showed CD3 antigen and about 40-50% presented the alpha beta T cell receptor. Thymocytes with NK markers (CD16, CD57, CD56) were not found. After stimulation with phytohemagglutinin, thymocytes showed a low but detectable proliferative capability, while splenocytes and peripheral blood lymphocytes showed a high responsiveness to the mitogen. These data show that the impaired immune system in DS is not associated with gross abnormalities of phenotypic T cell development in the fetal thymus or with an inability of such fetal cells to proliferate after a mitogenic stimulus.
FETAL THYMIC DIFFERENTIATION IN DOWNS-SYNDROME / Cossarizza, Andrea; Monti, D; Montagnani, G; Forabosco, Antonino; Dagnabricarelli, F; Franceschi, C.. - In: THYMUS. - ISSN 0165-6090. - STAMPA. - 14(1989), pp. 163-170.
Data di pubblicazione: | 1989 |
Titolo: | FETAL THYMIC DIFFERENTIATION IN DOWNS-SYNDROME |
Autore/i: | Cossarizza, Andrea; Monti, D; Montagnani, G; Forabosco, Antonino; Dagnabricarelli, F; Franceschi, C. |
Autore/i UNIMORE: | |
Rivista: | |
Volume: | 14 |
Pagina iniziale: | 163 |
Pagina finale: | 170 |
Codice identificativo ISI: | WOS:A1989CH41400019 |
Codice identificativo Scopus: | 2-s2.0-0024819440 |
Codice identificativo Pubmed: | 2533759 |
Citazione: | FETAL THYMIC DIFFERENTIATION IN DOWNS-SYNDROME / Cossarizza, Andrea; Monti, D; Montagnani, G; Forabosco, Antonino; Dagnabricarelli, F; Franceschi, C.. - In: THYMUS. - ISSN 0165-6090. - STAMPA. - 14(1989), pp. 163-170. |
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