Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disorder resulting from genetic and environmental factors. Hyperferritinemia has been associated with increased hepatic iron stores and worse outcomes in patients with NAFLD. The aim of this study was to evaluate the prevalence of variants of iron-related genes and their association with hyperferritinemia, hepatic iron stores and liver disease severity in patients with NAFLD.
Ceruloplasmin gene variants are associated with hyperferritinemia and increased liver iron in patients with {NAFLD} / Corradini, Elena; Buzzetti, Elena; Dongiovanni, Paola; Scarlini, Stefania; Caleffi, Angela; Pelusi, Serena; Bernardis, Isabella; Ventura, Paolo; Rametta, Raffaela; Tenedini, Elena; Tagliafico, Enrico; Ludovica Fracanzani, Anna; Fargion, Silvia; Pietrangelo, Antonello; Vittorio Valenti, Luca. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - 75:3(2021), pp. 506-513. [10.1016/j.jhep.2021.03.014]
Ceruloplasmin gene variants are associated with hyperferritinemia and increased liver iron in patients with {NAFLD}
Elena Corradini;Elena Buzzetti;Stefania Scarlini;Angela Caleffi;Isabella Bernardis;Paolo Ventura;Elena Tenedini;Enrico Tagliafico;Antonello Pietrangelo;
2021
Abstract
Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disorder resulting from genetic and environmental factors. Hyperferritinemia has been associated with increased hepatic iron stores and worse outcomes in patients with NAFLD. The aim of this study was to evaluate the prevalence of variants of iron-related genes and their association with hyperferritinemia, hepatic iron stores and liver disease severity in patients with NAFLD.
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