EnglishIn liver transplant, during anti-viral therapy for hepatitis C virus (HCV) recurrence, the immunosuppressant levels should be monitored to prevent both toxicity and rejection. Sofosbuvir (SOF) has been used within compassionate programs for HCV recurrence and, according to pharmacokinetic analyses, is not supposed to have significant pharmacological interactions with tacrolimus (Tac) or ciclosporin.1 This was reported in the review article by Koff recently published.2 We treated eight transplant recipients with SOF/ribavirin (RBV) for a severe HCV recurrence, and observed unexpected Tac/ciclosporin reduction during SOF.
Calcineurin inhibitors levels reduction during treatment with Sofosbuvir in liver transplanted patients / Vukotic, Ranka; Morelli, M; Pinna, Antonio Daniele; Margotti, Marzia; Foschi, Fg; Loggi, Elisabetta; Bernardi, Mauro; Andreone, Pietro. - In: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. - ISSN 0269-2813. - 40(2014), pp. 405-405. [10.1111/apt.12853]
| Data di pubblicazione: | 2014 | |
| Titolo: | Calcineurin inhibitors levels reduction during treatment with Sofosbuvir in liver transplanted patients | |
| Autore/i: | Vukotic, Ranka; Morelli, M; Pinna, Antonio Daniele; Margotti, Marzia; Foschi, Fg; Loggi, Elisabetta; Bernardi, Mauro; Andreone, Pietro | |
| Autore/i UNIMORE: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/apt.12853 | |
| Rivista: | ||
| Volume: | 40 | |
| Pagina iniziale: | 405 | |
| Pagina finale: | 405 | |
| Codice identificativo ISI: | WOS:000340552600010 | |
| Codice identificativo Scopus: | 2-s2.0-84904420819 | |
| Codice identificativo Pubmed: | 25040927 | |
| Citazione: | Calcineurin inhibitors levels reduction during treatment with Sofosbuvir in liver transplanted patients / Vukotic, Ranka; Morelli, M; Pinna, Antonio Daniele; Margotti, Marzia; Foschi, Fg; Loggi, Elisabetta; Bernardi, Mauro; Andreone, Pietro. - In: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. - ISSN 0269-2813. - 40(2014), pp. 405-405. [10.1111/apt.12853] | |
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