A comprehensive and contemporary “snapshot” of β-lactamases in carbapenem resistant Acinetobacter baumannii

Hujer, A. M.; Hujer, K. M.; Leonard, D. A.; Powers, R. A.; Wallar, B. J.; Mack, A. R.; Taracila, M. A.; Rather, P. N.; Higgins, P. G.; Prati, F.; Caselli, E.; Marshall, S. H.; Clarke, T.; Greco, C.; Venepally, P.; Brinkac, L.; Kreiswirth, B. N.; Fouts, D. E.; Bonomo, R. A.

doi:10.1016/j.diagmicrobio.2020.115242

Successful treatment of Acinetobacter baumannii infections require early and appropriate antimicrobial therapy. One of the first steps in this process is understanding which β-lactamase (bla) alleles are present and in what combinations. Thus, we performed WGS on 98 carbapenem-resistant A. baumannii (CR Ab). In most isolates, an acquired blaOXA carbapenemase was found in addition to the intrinsic blaOXA allele. The most commonly found allele was blaOXA-23 (n = 78/98). In some isolates, blaOXA-23 was found in addition to other carbapenemase alleles: blaOXA-82 (n = 12/78), blaOXA-72 (n = 2/78) and blaOXA-24/40 (n = 1/78). Surprisingly, 20% of isolates carried carbapenemases not routinely assayed for by rapid molecular diagnostic platforms, i.e., blaOXA-82 and blaOXA-172; all had ISAba1 elements. In 8 CR Ab, blaOXA-82 or blaOXA-172 was the only carbapenemase. Both blaOXA-24/40 and its variant blaOXA-72 were each found in 6/98 isolates. The most prevalent ADC variants were blaADC-30 (21%), blaADC-162 (21%), and blaADC-212 (26%). Complete combinations are reported.

A comprehensive and contemporary “snapshot” of β-lactamases in carbapenem resistant Acinetobacter baumannii / Hujer, A. M.; Hujer, K. M.; Leonard, D. A.; Powers, R. A.; Wallar, B. J.; Mack, A. R.; Taracila, M. A.; Rather, P. N.; Higgins, P. G.; Prati, F.; Caselli, E.; Marshall, S. H.; Clarke, T.; Greco, C.; Venepally, P.; Brinkac, L.; Kreiswirth, B. N.; Fouts, D. E.; Bonomo, R. A.. - In: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE. - ISSN 0732-8893. - 99:2(2021), pp. 115242-115242.

Data di pubblicazione:	2021
Titolo:	A comprehensive and contemporary “snapshot” of β-lactamases in carbapenem resistant Acinetobacter baumannii
Autore/i:	Hujer, A. M.; Hujer, K. M.; Leonard, D. A.; Powers, R. A.; Wallar, B. J.; Mack, A. R.; Taracila, M. A.; Rather, P. N.; Higgins, P. G.; Prati, F.; Caselli, E.; Marshall, S. H.; Clarke, T.; Greco, C.; Venepally, P.; Brinkac, L.; Kreiswirth, B. N.; Fouts, D. E.; Bonomo, R. A.
Autore/i UNIMORE:	Hujer A. M. Hujer K. M. Leonard D. A. Powers R. A. Wallar B. J. Mack A. R. Taracila M. A. Rather P. N. Higgins P. G. PRATI, Fabio CASELLI, Emilia Marshall S. H. Clarke T. Greco C. Venepally P. Brinkac L. Kreiswirth B. N. Fouts D. E. Bonomo R. A. mostra contributor esterni nascondi contributor esterni
Digital Object Identifier (DOI):	http://dx.doi.org/10.1016/j.diagmicrobio.2020.115242
Rivista:	DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Volume:	99
Fascicolo:	2
Pagina iniziale:	115242
Pagina finale:	115242
Codice identificativo Scopus:	2-s2.0-85096842755
Codice identificativo Pubmed:	33248392
Citazione:	A comprehensive and contemporary “snapshot” of β-lactamases in carbapenem resistant Acinetobacter baumannii / Hujer, A. M.; Hujer, K. M.; Leonard, D. A.; Powers, R. A.; Wallar, B. J.; Mack, A. R.; Taracila, M. A.; Rather, P. N.; Higgins, P. G.; Prati, F.; Caselli, E.; Marshall, S. H.; Clarke, T.; Greco, C.; Venepally, P.; Brinkac, L.; Kreiswirth, B. N.; Fouts, D. E.; Bonomo, R. A.. - In: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE. - ISSN 0732-8893. - 99:2(2021), pp. 115242-115242.
Tipologia	Articolo su rivista

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