Objective: This study evaluated Neem oil and Hypericum perforatum (Holoil®) for treatment of scleroderma skin ulcers related to calcinosis (SU-calc). Procedure: We retrospectively analyzed 21 consecutive systemic sclerosis (SSc) patients with a total of 33 SU-calcs treated daily with Holoil® cream compared with a control group of 20 patients with 26 SU-calcs. Holoil® was directly applied to skin lesions, while the control group received only standard medication. Results: Application of Holoil® either resulted in crushing and complete resolution of calcium deposits or facilitated sharp excision of calcinosis during wound care sessions in 27/33 cases (81.8%). Complete healing of SU-calc occurred in 15/33 (45%) of cases within a time period of 40.1 ± 16.3 (mean ± SD) days, while 18/33 (55%) of lesions improved in terms of size, erythema, fibrin and calcium deposits. Patients reported a reduction of pain (mean numeric rating scale 7.3 ± 1.9 at baseline versus 2.9 ± 1.4 at follow-up) The control group had longer healing times and a higher percentage of infections. Conclusions: The efficacy of local treatment with neem oil and Hypericum perforatum suggest that Holoil® could be a promising tool in the management of SSc SU-calc.
Use of Neem oil and Hypericum perforatum for treatment of calcinosis-related skin ulcers in systemic sclerosis / Giuggioli, D.; Lumetti, F.; Spinella, A.; Cocchiara, E.; Sighinolfi, G.; Citriniti, G.; Colaci, M.; Salvarani, C.; Ferri, C.. - In: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH. - ISSN 0300-0605. - 48:4(2019), pp. 1-8. [10.1177/0300060519882176]
Data di pubblicazione: | 2019 | |
Titolo: | Use of Neem oil and Hypericum perforatum for treatment of calcinosis-related skin ulcers in systemic sclerosis | |
Autore/i: | Giuggioli, D.; Lumetti, F.; Spinella, A.; Cocchiara, E.; Sighinolfi, G.; Citriniti, G.; Colaci, M.; Salvarani, C.; Ferri, C. | |
Autore/i UNIMORE: | ||
Digital Object Identifier (DOI): | http://dx.doi.org/10.1177/0300060519882176 | |
Rivista: | ||
Volume: | 48 | |
Fascicolo: | 4 | |
Pagina iniziale: | 1 | |
Pagina finale: | 8 | |
Codice identificativo ISI: | WOS:000507747800001 | |
Codice identificativo Scopus: | 2-s2.0-85090927065 | |
Codice identificativo Pubmed: | 31875751 | |
Citazione: | Use of Neem oil and Hypericum perforatum for treatment of calcinosis-related skin ulcers in systemic sclerosis / Giuggioli, D.; Lumetti, F.; Spinella, A.; Cocchiara, E.; Sighinolfi, G.; Citriniti, G.; Colaci, M.; Salvarani, C.; Ferri, C.. - In: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH. - ISSN 0300-0605. - 48:4(2019), pp. 1-8. [10.1177/0300060519882176] | |
Tipologia | Articolo su rivista |
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giuggioli holoil .pdf | Post-print dell'autore (bozza post referaggio) | Open Access Visualizza/Apri |
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