We reformulate the single-molecule analysis in an electron microscope in terms of a quantum-state discrimination problem, and discuss its implementation through electron-beam shaping. Our approach relies on the use of new electron-optical elements to efficiently extract the "which-molecule"information from the state of each electron. The optimal observables are formally derived, and subsequently implemented by suitably designed phase elements in a generalized orbital angular momentum sorter. As a representative example, we simulate the discrimination between model proteins and benchmark the performance of the sorter against that of the best known real-space approach.
Efficient molecule discrimination in electron microscopy through an optimized orbital angular momentum sorter / Troiani, F.; Rotunno, E.; Frabboni, S.; Ravelli, R. B. G.; Peters, P. J.; Karimi, E.; Grillo, V.. - In: PHYSICAL REVIEW A. - ISSN 2469-9926. - 102:4(2020), pp. 1-10. [10.1103/PhysRevA.102.043510]
Efficient molecule discrimination in electron microscopy through an optimized orbital angular momentum sorter
Troiani F.;Frabboni S.;Grillo V.
2020
Abstract
We reformulate the single-molecule analysis in an electron microscope in terms of a quantum-state discrimination problem, and discuss its implementation through electron-beam shaping. Our approach relies on the use of new electron-optical elements to efficiently extract the "which-molecule"information from the state of each electron. The optimal observables are formally derived, and subsequently implemented by suitably designed phase elements in a generalized orbital angular momentum sorter. As a representative example, we simulate the discrimination between model proteins and benchmark the performance of the sorter against that of the best known real-space approach.Pubblicazioni consigliate
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