Pretreatment with fiunarizine (20 mg/kg), a diphenylalkylamine calcium channel antagonist, markedly potentiated cocaine (10 mg/kg) -induced dopamine (DA) output from the ventral striatum, as measured by microdialysis in freely moving rats. Moreover, fiunarizine enhanced cocaine-induced motor stimulation. Pretreatment with the D2 receptor antagonist (-)-sulpiride (25 mg/kg) potentiated cocaine-induced DA output but, unlike fiunarizine, inhibited cocaine-induced motor stimulation. When added to striatal membrane preparations, flunanzine displaced [3H]spiperone binding with a Ki of about 100 nM. Since recent evidence indicates that the effects of cocaine are calcium-dependent and are prevented by dihydropyridine calcium antagonists, these findings suggest that the paradoxical potentiating effect of fiunarizine is probably due to an interaction with the DA system and is not due to its calcium antagonist property. © 1990.

Flunarizine potentiates cocaine-induced doparaine release and motor stimulation in rats / Pani, L.; Kuzmin, A.; Stefanini, E.; Gessa, G. L.; Rossetti, Z. L.. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 190:1-2(1990), pp. 223-227. [10.1016/0014-2999(90)94129-L]

Flunarizine potentiates cocaine-induced doparaine release and motor stimulation in rats

Pani L.;Stefanini E.;
1990

Abstract

Pretreatment with fiunarizine (20 mg/kg), a diphenylalkylamine calcium channel antagonist, markedly potentiated cocaine (10 mg/kg) -induced dopamine (DA) output from the ventral striatum, as measured by microdialysis in freely moving rats. Moreover, fiunarizine enhanced cocaine-induced motor stimulation. Pretreatment with the D2 receptor antagonist (-)-sulpiride (25 mg/kg) potentiated cocaine-induced DA output but, unlike fiunarizine, inhibited cocaine-induced motor stimulation. When added to striatal membrane preparations, flunanzine displaced [3H]spiperone binding with a Ki of about 100 nM. Since recent evidence indicates that the effects of cocaine are calcium-dependent and are prevented by dihydropyridine calcium antagonists, these findings suggest that the paradoxical potentiating effect of fiunarizine is probably due to an interaction with the DA system and is not due to its calcium antagonist property. © 1990.
190
1-2
223
227
Flunarizine potentiates cocaine-induced doparaine release and motor stimulation in rats / Pani, L.; Kuzmin, A.; Stefanini, E.; Gessa, G. L.; Rossetti, Z. L.. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 190:1-2(1990), pp. 223-227. [10.1016/0014-2999(90)94129-L]
Pani, L.; Kuzmin, A.; Stefanini, E.; Gessa, G. L.; Rossetti, Z. L.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1212137
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 18
  • ???jsp.display-item.citation.isi??? 19
social impact