Prolactin blood level and apomorphine-induced yawning were studied in rats treated with the substituted benzamide amisulpride in association with bromocriptine or carmoxirole; two dopamine D2 receptor agonists with high or low propensity to cross the brain-blood barrier, respectively. Administration of amisulpride produced a maximum increase in rat serum prolactin level (315±18%) vs. vehicle-treated animals (ED50=0.25±0.017 mg/kg, s.c.). The concurrent administration of carmoxirole or bromocriptine completely reversed the hyperprolactinemia induced by amisulpride (0.5 mg/kg, s.c.) (ID50=14.9±0.8 mg/kg and 0.81±0.03 mg/kg, respectively). Carmoxirole (15 mg/kg, i.p.) did not affect yawning induced by apomorphine (0.08 mg/kg, s.c.) nor amisulpride (0.5 mg/kg, s.c.) blockade of apomorphine-induced yawning. Conversely, a significant increase in the number of yawns was observed when bromocriptine (0.8 mg/kg, i.p.) was associated with apomorphine in the absence or presence of amisulpride. These results suggested that a peripheral dopamine D2 receptor agonists could be a useful tool in alleviating amisulpride-induced hyperprolactinemia without possibly affecting its central effect. © 2002 Elsevier Science B.V. All rights reserved.

Carmoxirole is able to reduce amisulpride-induced hyperprolactinemia without affecting its central effect / Marchese, G.; Ruiu, S.; Casti, P.; Bartholini, F.; Saba, P.; Gessa, G. L.; Pani, L.. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 447:1(2002), pp. 109-114. [10.1016/S0014-2999(02)01896-4]

Carmoxirole is able to reduce amisulpride-induced hyperprolactinemia without affecting its central effect

Pani L.
2002

Abstract

Prolactin blood level and apomorphine-induced yawning were studied in rats treated with the substituted benzamide amisulpride in association with bromocriptine or carmoxirole; two dopamine D2 receptor agonists with high or low propensity to cross the brain-blood barrier, respectively. Administration of amisulpride produced a maximum increase in rat serum prolactin level (315±18%) vs. vehicle-treated animals (ED50=0.25±0.017 mg/kg, s.c.). The concurrent administration of carmoxirole or bromocriptine completely reversed the hyperprolactinemia induced by amisulpride (0.5 mg/kg, s.c.) (ID50=14.9±0.8 mg/kg and 0.81±0.03 mg/kg, respectively). Carmoxirole (15 mg/kg, i.p.) did not affect yawning induced by apomorphine (0.08 mg/kg, s.c.) nor amisulpride (0.5 mg/kg, s.c.) blockade of apomorphine-induced yawning. Conversely, a significant increase in the number of yawns was observed when bromocriptine (0.8 mg/kg, i.p.) was associated with apomorphine in the absence or presence of amisulpride. These results suggested that a peripheral dopamine D2 receptor agonists could be a useful tool in alleviating amisulpride-induced hyperprolactinemia without possibly affecting its central effect. © 2002 Elsevier Science B.V. All rights reserved.
447
1
109
114
Carmoxirole is able to reduce amisulpride-induced hyperprolactinemia without affecting its central effect / Marchese, G.; Ruiu, S.; Casti, P.; Bartholini, F.; Saba, P.; Gessa, G. L.; Pani, L.. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 447:1(2002), pp. 109-114. [10.1016/S0014-2999(02)01896-4]
Marchese, G.; Ruiu, S.; Casti, P.; Bartholini, F.; Saba, P.; Gessa, G. L.; Pani, L.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1212095
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