The intravenous administration of cocaine (0.5-8 mg/kg) produced a dose-related inhibition of the firing rate of substantia nigra (A9) dopaminergic (DA) neurons. Pretreatment with the calcium antagonist flunarizine (5 mg/kg i.v.) prevented cocaine-induced effects but failed to antagonize the inhibition of firing induced by a low dose of apomorphine (10μg/kg i.v.). This finding rules out the possibility that flunarizine antagonism of cocaine effect might depend on DA autoreceptors blockade by flunarizine. It is suggested that flunarizine, by blocking calcium influx into DA neurons, prevents DA release from dendrites, thereby counteracting the main mechanism by which cocaine inhibits dopaminergic neuronal activity. © 1991 The Italian Pharmacological Society.

Flunarizine attenuates cocaine-induced inhibition of A9 dopaminergic neurons / Diana, M.; Pani, L.; Rossetti, Z.; Passino, N.; Gessa, G. L.. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - 24:2(1991), pp. 197-203. [10.1016/1043-6618(91)90034-U]

Flunarizine attenuates cocaine-induced inhibition of A9 dopaminergic neurons

Pani L.;
1991

Abstract

The intravenous administration of cocaine (0.5-8 mg/kg) produced a dose-related inhibition of the firing rate of substantia nigra (A9) dopaminergic (DA) neurons. Pretreatment with the calcium antagonist flunarizine (5 mg/kg i.v.) prevented cocaine-induced effects but failed to antagonize the inhibition of firing induced by a low dose of apomorphine (10μg/kg i.v.). This finding rules out the possibility that flunarizine antagonism of cocaine effect might depend on DA autoreceptors blockade by flunarizine. It is suggested that flunarizine, by blocking calcium influx into DA neurons, prevents DA release from dendrites, thereby counteracting the main mechanism by which cocaine inhibits dopaminergic neuronal activity. © 1991 The Italian Pharmacological Society.
24
2
197
203
Flunarizine attenuates cocaine-induced inhibition of A9 dopaminergic neurons / Diana, M.; Pani, L.; Rossetti, Z.; Passino, N.; Gessa, G. L.. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - 24:2(1991), pp. 197-203. [10.1016/1043-6618(91)90034-U]
Diana, M.; Pani, L.; Rossetti, Z.; Passino, N.; Gessa, G. L.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1212063
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