It was previously shown that haloperidol, but not clozapine, induced intense rat catalepsy when co-administered with delta-9-tetrahydrocannabinol. The present study investigated whether similar alterations could be observed on striatal c-Fos immunoreactivity after administration of the same drug combinations. Western Blot and immunocytochemistry stereological analyses indicated that delta-9-tetrahydrocannabinol (0.5 mg/kg) increased striatal c-Fos immunoreactivity induced by haloperidol (0.1 mg/kg). Conversely, no significant alterations of striatal c-Fos immunoreactivity were observed after injections of clozapine (10 mg/kg) + vehicle, clozapine + delta-9-tetrahydrocannabinol or vehicle + delta-9-tetrahydrocannabinol. The present results indicate that the behavioral effects induced by delta-9-tetrahydrocannabinol in haloperidol- and clozapine-treated rats are associated with different striatal c-Fos expressions. © 2008 Elsevier B.V. All rights reserved.

Delta-9-tetrahydrocannabinol differently affects striatal c-Fos expression following haloperidol or clozapine administration / Marchese, G.; Sanna, A.; Casu, G.; Casti, P.; Spada, G. P.; Ruiu, S.; Pani, L.. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 598:1-3(2008), pp. 16-20. [10.1016/j.ejphar.2008.08.020]

Delta-9-tetrahydrocannabinol differently affects striatal c-Fos expression following haloperidol or clozapine administration

Casu G.;Pani L.
2008

Abstract

It was previously shown that haloperidol, but not clozapine, induced intense rat catalepsy when co-administered with delta-9-tetrahydrocannabinol. The present study investigated whether similar alterations could be observed on striatal c-Fos immunoreactivity after administration of the same drug combinations. Western Blot and immunocytochemistry stereological analyses indicated that delta-9-tetrahydrocannabinol (0.5 mg/kg) increased striatal c-Fos immunoreactivity induced by haloperidol (0.1 mg/kg). Conversely, no significant alterations of striatal c-Fos immunoreactivity were observed after injections of clozapine (10 mg/kg) + vehicle, clozapine + delta-9-tetrahydrocannabinol or vehicle + delta-9-tetrahydrocannabinol. The present results indicate that the behavioral effects induced by delta-9-tetrahydrocannabinol in haloperidol- and clozapine-treated rats are associated with different striatal c-Fos expressions. © 2008 Elsevier B.V. All rights reserved.
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Delta-9-tetrahydrocannabinol differently affects striatal c-Fos expression following haloperidol or clozapine administration / Marchese, G.; Sanna, A.; Casu, G.; Casti, P.; Spada, G. P.; Ruiu, S.; Pani, L.. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 598:1-3(2008), pp. 16-20. [10.1016/j.ejphar.2008.08.020]
Marchese, G.; Sanna, A.; Casu, G.; Casti, P.; Spada, G. P.; Ruiu, S.; Pani, L.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1212061
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