Background: Although manic or hypomanic episodes define bipolar disorder (BD), most patients show a predominance of depressive symptomatology, often associated with delayed or disregarded BD diagnosis. The Hypomania Checklist-32 (HCL-32) has therefore been developed and tested internationally to facilitate BD recognition. Sampling andMethods: Five hundred seventy-one (563 eligible) patients diagnosed with a major depressive episode according to DSM-IV criteria were consecutively enrolled in a cross-sectional, multicenter, observational study (Come To Me). Lifetime manic or hypomanic features were assessed by the HCL-32, and severity of depressive and anxious symptomatology was assessed using the Zung's self-report questionnaires for depression and anxiety. Results: Among the patients diagnosed with BD (n = 119), either type I or type II, the occurrence of (hypo)manic symptoms was significantly higher compared to major depressive disorder (MDD) symptoms according to HCL-32 total and subscale scores obtained using a score of 14, which ensured an optimal discrimination between BD and MDD with a sensitivity of 0.85 and a specificity of 0.78. Conclusions: Although some false positives might occur, the HCL-32 was confirmed to be a useful instrument in the detection of past hypomania in MDD patients, finally contributing to proper therapeutic choices. Copyright © 2012 S. Karger AG, Basel.

Discriminative hypomania checklist-32 factors in unipolar and bipolar major depressive patients on behalf of come to me study group / Perugi, G.; Fornaro, M.; Maremmani, I.; Canonico, P. L.; Carbonatto, P.; Mencacci, C.; Muscettola, G.; Pani, L.; Torta, R.; Vampini, C.; Parazzini, F.; Dumitriu, A.; Angst, J.. - In: PSYCHOPATHOLOGY. - ISSN 0254-4962. - 45:6(2012), pp. 390-398. [10.1159/000338047]

Discriminative hypomania checklist-32 factors in unipolar and bipolar major depressive patients on behalf of come to me study group

Pani L.;
2012

Abstract

Background: Although manic or hypomanic episodes define bipolar disorder (BD), most patients show a predominance of depressive symptomatology, often associated with delayed or disregarded BD diagnosis. The Hypomania Checklist-32 (HCL-32) has therefore been developed and tested internationally to facilitate BD recognition. Sampling andMethods: Five hundred seventy-one (563 eligible) patients diagnosed with a major depressive episode according to DSM-IV criteria were consecutively enrolled in a cross-sectional, multicenter, observational study (Come To Me). Lifetime manic or hypomanic features were assessed by the HCL-32, and severity of depressive and anxious symptomatology was assessed using the Zung's self-report questionnaires for depression and anxiety. Results: Among the patients diagnosed with BD (n = 119), either type I or type II, the occurrence of (hypo)manic symptoms was significantly higher compared to major depressive disorder (MDD) symptoms according to HCL-32 total and subscale scores obtained using a score of 14, which ensured an optimal discrimination between BD and MDD with a sensitivity of 0.85 and a specificity of 0.78. Conclusions: Although some false positives might occur, the HCL-32 was confirmed to be a useful instrument in the detection of past hypomania in MDD patients, finally contributing to proper therapeutic choices. Copyright © 2012 S. Karger AG, Basel.
45
6
390
398
Discriminative hypomania checklist-32 factors in unipolar and bipolar major depressive patients on behalf of come to me study group / Perugi, G.; Fornaro, M.; Maremmani, I.; Canonico, P. L.; Carbonatto, P.; Mencacci, C.; Muscettola, G.; Pani, L.; Torta, R.; Vampini, C.; Parazzini, F.; Dumitriu, A.; Angst, J.. - In: PSYCHOPATHOLOGY. - ISSN 0254-4962. - 45:6(2012), pp. 390-398. [10.1159/000338047]
Perugi, G.; Fornaro, M.; Maremmani, I.; Canonico, P. L.; Carbonatto, P.; Mencacci, C.; Muscettola, G.; Pani, L.; Torta, R.; Vampini, C.; Parazzini, F.; Dumitriu, A.; Angst, J.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1211969
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 14
social impact