Warm microemulsions based on lipids characterized by a melting point over 50°C have been successfully used as starting matrix in a quenching process to obtain solid lipid nanoparticles (SLN). In this work, we have investigated the effect of 1-butanol (B) on the phase behavior of the lecithin (LCT)/water (W)/tripalmitin (TP) system at 70°C. The study has been carried out at LCT/B = 1 (weight ratio). Emulsion and liquid crystalline phase regions have been observed in the ternary phase diagram, while the presence of 1-butanol in the LCT/W/B/TP system allows the formation of a wide area of liquid isotropic phase from the whole (LCT + B)/TP binary axis up to 37 wt% of water. The microstructure of this isotropic phase has been investigated by means of 1H NMR PGSE technique. The self-diffusion coefficients of the different components along oil and water dilution lines indicate a microstructural organization characterized by a highly connected water in oil domains. © 2005 Elsevier Ireland Ltd. All rights reserved.

Effect of 1-butanol on the microstructure of lecithin/water/tripalmitin system / Caboi, F.; Lazzari, P.; Pani, L.; Monduzzi, M.. - In: CHEMISTRY AND PHYSICS OF LIPIDS. - ISSN 0009-3084. - 135:2(2005), pp. 147-156. [10.1016/j.chemphyslip.2005.02.010]

Effect of 1-butanol on the microstructure of lecithin/water/tripalmitin system

Lazzari P.;Pani L.;
2005

Abstract

Warm microemulsions based on lipids characterized by a melting point over 50°C have been successfully used as starting matrix in a quenching process to obtain solid lipid nanoparticles (SLN). In this work, we have investigated the effect of 1-butanol (B) on the phase behavior of the lecithin (LCT)/water (W)/tripalmitin (TP) system at 70°C. The study has been carried out at LCT/B = 1 (weight ratio). Emulsion and liquid crystalline phase regions have been observed in the ternary phase diagram, while the presence of 1-butanol in the LCT/W/B/TP system allows the formation of a wide area of liquid isotropic phase from the whole (LCT + B)/TP binary axis up to 37 wt% of water. The microstructure of this isotropic phase has been investigated by means of 1H NMR PGSE technique. The self-diffusion coefficients of the different components along oil and water dilution lines indicate a microstructural organization characterized by a highly connected water in oil domains. © 2005 Elsevier Ireland Ltd. All rights reserved.
135
2
147
156
Effect of 1-butanol on the microstructure of lecithin/water/tripalmitin system / Caboi, F.; Lazzari, P.; Pani, L.; Monduzzi, M.. - In: CHEMISTRY AND PHYSICS OF LIPIDS. - ISSN 0009-3084. - 135:2(2005), pp. 147-156. [10.1016/j.chemphyslip.2005.02.010]
Caboi, F.; Lazzari, P.; Pani, L.; Monduzzi, M.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1211952
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 32
  • ???jsp.display-item.citation.isi??? 32
social impact