Warm microemulsions based on lipids characterized by a melting point over 50°C have been successfully used as starting matrix in a quenching process to obtain solid lipid nanoparticles (SLN). In this work, we have investigated the effect of 1-butanol (B) on the phase behavior of the lecithin (LCT)/water (W)/tripalmitin (TP) system at 70°C. The study has been carried out at LCT/B = 1 (weight ratio). Emulsion and liquid crystalline phase regions have been observed in the ternary phase diagram, while the presence of 1-butanol in the LCT/W/B/TP system allows the formation of a wide area of liquid isotropic phase from the whole (LCT + B)/TP binary axis up to 37 wt% of water. The microstructure of this isotropic phase has been investigated by means of 1H NMR PGSE technique. The self-diffusion coefficients of the different components along oil and water dilution lines indicate a microstructural organization characterized by a highly connected water in oil domains. © 2005 Elsevier Ireland Ltd. All rights reserved.
Effect of 1-butanol on the microstructure of lecithin/water/tripalmitin system / Caboi, F.; Lazzari, P.; Pani, L.; Monduzzi, M.. - In: CHEMISTRY AND PHYSICS OF LIPIDS. - ISSN 0009-3084. - 135:2(2005), pp. 147-156. [10.1016/j.chemphyslip.2005.02.010]
Effect of 1-butanol on the microstructure of lecithin/water/tripalmitin system
Lazzari P.;Pani L.;
2005
Abstract
Warm microemulsions based on lipids characterized by a melting point over 50°C have been successfully used as starting matrix in a quenching process to obtain solid lipid nanoparticles (SLN). In this work, we have investigated the effect of 1-butanol (B) on the phase behavior of the lecithin (LCT)/water (W)/tripalmitin (TP) system at 70°C. The study has been carried out at LCT/B = 1 (weight ratio). Emulsion and liquid crystalline phase regions have been observed in the ternary phase diagram, while the presence of 1-butanol in the LCT/W/B/TP system allows the formation of a wide area of liquid isotropic phase from the whole (LCT + B)/TP binary axis up to 37 wt% of water. The microstructure of this isotropic phase has been investigated by means of 1H NMR PGSE technique. The self-diffusion coefficients of the different components along oil and water dilution lines indicate a microstructural organization characterized by a highly connected water in oil domains. © 2005 Elsevier Ireland Ltd. All rights reserved.
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