We report on the development of a multilayer coated reflection-type long period fiber grating (LPG) biosensor, useful for the detection of antibiotic resistance bacteria. A standard LPG is first transformed in a more practical probe working in reflection mode, then it is coated by a primary layer of aPS and a secondary layer of PMMA in order to increase its surrounding refractive index sensitivity and at the same time provide the necessary conditions for a correct bio-functionalization. Standard linkage chemistry has been applied to anchor the bioreceptors on the probe surface. We show some preliminary results demonstrating the capability of our LPG biosensor to successfully monitor all the biological steps of the biomolecular experiments, including β-lactamase binding detection tests. © 2014 IEEE.
Long period fiber grating biosensor for the detection of drug resistant bacteria: The 'OPTObacteria' project / Consales, M.; Quero, G.; Zuppolini, S.; Sansone, L.; Borriello, A.; Giordano, M.; Venturelli, A.; Costi, M. P.; Santucci, M.; Cusano, A.. - (2014), pp. 1-3. (Intervento presentato al convegno 2014 3rd Mediterranean Photonics Conference, MePhoCo 2014 tenutosi a Trani, ita nel 2014) [10.1109/MePhoCo.2014.6866453].
Long period fiber grating biosensor for the detection of drug resistant bacteria: The 'OPTObacteria' project
Venturelli A.Funding Acquisition
;Costi M. P.Funding Acquisition
;Santucci M.Conceptualization
;
2014
Abstract
We report on the development of a multilayer coated reflection-type long period fiber grating (LPG) biosensor, useful for the detection of antibiotic resistance bacteria. A standard LPG is first transformed in a more practical probe working in reflection mode, then it is coated by a primary layer of aPS and a secondary layer of PMMA in order to increase its surrounding refractive index sensitivity and at the same time provide the necessary conditions for a correct bio-functionalization. Standard linkage chemistry has been applied to anchor the bioreceptors on the probe surface. We show some preliminary results demonstrating the capability of our LPG biosensor to successfully monitor all the biological steps of the biomolecular experiments, including β-lactamase binding detection tests. © 2014 IEEE.
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