In patients undergoing orthotopic liver transplant (OLT), immunosuppressive (IS) treatment is mandatory and infections are leading causes of morbidity/mortality. Thus, it is essential to understand the functionality of cell-mediated immunity after OLT. The aim of the study was to identify changes in T cell phenotype and polyfunctionality in HIV+ and HIV- patients treated with IS after OLT.
Efficient T cell compartment in HIV+ patients receiving orthotopic liver transplant and immunosuppressive therapy / Franceschini, Erica; De Biasi, Sara; Digaetano, Margherita; Bianchini, Elena; Lo Tartaro, Domenico; Gibellini, Lara; Menozzi, Marianna; Zona, Stefano; Tarantino, Giuseppe; Nasi, Milena; Codeluppi, Mauro; Guaraldi, Giovanni; Magistri, Paolo; Di Benedetto, Fabrizio; Pinti, Marcello; Mussini, Cristina; Cossarizza, Andrea. - In: THE JOURNAL OF INFECTIOUS DISEASES. - ISSN 0022-1899. - 223:3(2020), pp. 482-493. [10.1093/infdis/jiaa395]
Efficient T cell compartment in HIV+ patients receiving orthotopic liver transplant and immunosuppressive therapy
Franceschini, Erica;De Biasi, Sara;Digaetano, Margherita;Bianchini, Elena;Lo Tartaro, Domenico;Gibellini, Lara;Menozzi, Marianna;Zona, Stefano;Tarantino, Giuseppe;Nasi, Milena;Guaraldi, Giovanni;Magistri, Paolo;Di Benedetto, Fabrizio;Pinti, Marcello;Mussini, Cristina;Cossarizza, Andrea
2020
Abstract
In patients undergoing orthotopic liver transplant (OLT), immunosuppressive (IS) treatment is mandatory and infections are leading causes of morbidity/mortality. Thus, it is essential to understand the functionality of cell-mediated immunity after OLT. The aim of the study was to identify changes in T cell phenotype and polyfunctionality in HIV+ and HIV- patients treated with IS after OLT.
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